N-(3-methylphenyl)pyrazine-2-carboxamide

Base Information

• Chemical Name: N-(3-methylphenyl)pyrazine-2-carboxamide
• CAS No.: 353783-37-6
• Molecular Formula: C₁₂H₁₁N₃O
• Molecular Weight: 213.239
• DSSTox Substance ID: DTXSID001329665
• ChEMBL ID: CHEMBL1530239
• Mol file: 353783-37-6.mol

Synonyms:N-(3-methylphenyl)pyrazine-2-carboxamide;Pyrazine-2-carboxylic acid m-tolylamide;CBMicro_024763;Cambridge id 5556613;MLS001208152;SCHEMBL259290;CHEMBL1530239;DTXSID001329665;HMS2848D05;N-(m-tolyl)pyrazine-2-carboxamide;CCG-11466;STK421387;AKOS000665296;SMR000518581;BIM-0024644.P001;SR-01000433579;Pyrazine-2-carboxylic acid (3-methyl-phenyl)-amide;SR-01000433579-1;N~2~-(3-METHYLPHENYL)-2-PYRAZINECARBOXAMIDE;Z27791161;353783-37-6

Chemical Property of N-(3-methylphenyl)pyrazine-2-carboxamide

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 213.090211983
• Heavy Atom Count: 16
• Complexity: 244

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=CC=C1)NC(=O)C2=NC=CN=C2

Technology Process of N-(3-methylphenyl)pyrazine-2-carboxamide

There total 2 articles about N-(3-methylphenyl)pyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-pyrazylcarboxylic acid (98-97-5) → N-(3-methylphenyl)pyrazine-2-carboxamide (353783-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 20 °C

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

DOI:10.1002/jhet.921

Reference yield:

pyrazinoyl chloride (19847-10-0) + 1-amino-3-methylbenzene (108-44-1) → N-(3-methylphenyl)pyrazine-2-carboxamide (353783-37-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1002/jhet.921

upstream raw materials:

pyrazinoyl chloride

1-amino-3-methylbenzene

2-pyrazylcarboxylic acid