4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol

Base Information

• Chemical Name: 4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol
• CAS No.: 126931-29-1
• Molecular Formula: C12H26O2Si
• Molecular Weight: 230.423
• Mol file: 126931-29-1.mol

Synonyms:

Chemical Property of 4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol

Chemical Property:

• Boiling Point: 265.7±33.0 °C(Predicted)
• PKA: 14.98±0.40(Predicted)
• PSA: 29.46000
• Density: 0.92±0.1 g/cm3(Predicted)
• LogP: 3.31170
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%min ^*data from raw suppliers

4-(t-Butyldimethylsilyloxy)cyclohexanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol

There total 5 articles about 4-(tert-Butyl-dimethyl-silanyloxy)-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(tert-butyl-dimethyl-silanyloxy)-4-triethylsilanyloxy-cyclohexane → 4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol (126931-29-1)

Guidance literature:

With iron(III) chloride; In methanol; at 23 ℃; for 0.25h;

DOI:10.1055/s-2006-926256

Reference yield: 93.0%

4-(tert-butyldimethylsilyloxy)cyclohexanone (55145-45-4) → 4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol (126931-29-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; at -50 - 20 ℃;

Reference yield: 89.0%

4-(tert-butyldimethylsilyloxy)cyclohexyl 4-methylbenzoate (1036648-31-3) → 4-((tert-butyldimethylsilyl)oxy)cyclohexan-1-ol (126931-29-1)

Guidance literature:

With methanol; samarium diiodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; chemoselective reaction; Reflux;

DOI:10.1021/ol900828x

upstream raw materials:

1,4-Cyclohexanediol

tert-butyldimethylsilyl chloride

4-(tert-butyldimethylsilyloxy)cyclohexanone

4-(tert-butyldimethylsilyloxy)cyclohexyl 4-methylbenzoate

Downstream raw materials:

4-methoxycyclohexan-1-ol

tert-butyl-[4-(4-chloro-2-nitro-phenoxy)-cyclohexyloxy]-dimethyl-silane

2-[4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyloxy]-5-chloro-phenylamine

Refernces

• 1、 -. "PYRAZOLOPYRIMIDINE DERIVATIVES AS BTK INHIBITORS FOR THE TREATMENT OF CANCER". Paragraph 00349; 00350. . Retrieved 2017/05/02.
• 2、 -. "SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS". Page/Page column 62. . Retrieved 2017/01/02.