N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide

Base Information

• Chemical Name: N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide
• CAS No.: 1584219-86-2
• Molecular Formula: C₂₉H₂₆FN₅O₅S
• Molecular Weight: 575.62
• Mol file: 1584219-86-2.mol

Synonyms:

Chemical Property of N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide

There total 4 articles about N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid (145591-80-6) + 4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine (1584220-15-4) → N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide (1584219-86-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide;

DOI:10.1021/ml500066m

Reference yield:

3-((methylsulfonyl)methyl)aniline (261925-02-4) → N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide (1584219-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / 1,4-dioxane / 90 °C / Sealed tube

2: iron; ammonium chloride / water; ethanol / 2 h / 70 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With iron; ammonium chloride; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ml500066m

Reference yield:

cyclopropane-1,1-dicarboxylic acid (598-10-7) → N-(3-fluoro-4-((2-((3-((methylsulfonyl)methyl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide (1584219-86-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0.5 h / 0 °C / Inert atmosphere

2.1: tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ml500066m

upstream raw materials:

3-((methylsulfonyl)methyl)aniline

1-(phenylcarbamoyl)cyclopropane-1-carboxylic acid

4-(4-amino-2-fluorophenoxy)-N-(3-((methylsulfonyl)methyl)phenyl)pyrimidin-2-amine

cyclopropane-1,1-dicarboxylic acid