2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Base Information

Chemical Name:2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile
CAS No.:1408463-77-3
Molecular Formula:C₂₉H₂₁Cl₂FN₆OS
Molecular Weight:591.496
Hs Code.:

2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

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Chemical Property of 2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

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Technology Process of 2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

There total 3 articles about 2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 77509-92-3
5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazole-4-carbaldehyde

: 1276542-84-7
3-(4-(4-fluorophenyl)thiazol-2-ylamino)cyclohex-2-enone

: 109-77-3
malononitrile

: 1408463-77-3
2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: With piperidine; Reflux;
DOI:10.1002/jhet.1038

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1408463-77-3
2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: iodine / 4 h / 120 °C

2: acetic acid; methanol

3: piperidine / Reflux

With piperidine; methanol; iodine; acetic acid;
DOI:10.1002/jhet.1038

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1408463-77-3
2-amino-4-(5-chloro-1-(3-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)-1-(4-(4-fluorophenyl)thiazol-2-yl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; ethanol

2: trichlorophosphate / 4 h / 90 °C

3: piperidine / Reflux

With piperidine; ethanol; acetic acid; trichlorophosphate; 2: |Vilsmeier-Haack Formylation;
DOI:10.1002/jhet.1038