77509-92-3Relevant academic research and scientific papers
Design and synthesis of pyrazolone-based compounds as potent blockers of SARS-CoV-2 viral entry into the host cells
Karpoormath, Rajshekhar,Kehinde, Idowu,Kushwaha, Babita,Kushwaha, Narva Deshwar,Mahlalela, Mavela Cleopus,Obakachi, Vincent A.,Shinde, Suraj Raosaheb
, (2021/06/16)
SARS-CoV-2 are enveloped positive-stranded RNA viruses that replicate in the cytoplasm. It relies on the fusion of their envelope with the host cell membrane to deliver their nucleocapsid into the host cell. The spike glycoprotein (S) mediates virus entry into cells via the human Angiotensin-converting enzyme 2 (hACE2) protein located on many cell types and tissues' outer surface. This study, therefore, aimed to design and synthesize novel pyrazolone-based compounds as potential inhibitors that would interrupt the interaction between the viral spike protein and the host cell receptor to prevent SARS-CoV 2 entrance into the cell. A series of pyrazolone compounds as potential SARS-CoV-2 inhibitors were designed and synthesized. Employing computational techniques, the inhibitory potentials of the designed compounds against both spike protein and hACE2 were evaluated. Results of the binding free energy from the in-silico analysis, showed that three compounds (7i, 7k and 8f) and six compounds (7b, 7h, 7k, 8d, 8g, and 8h) showed higher and better binding high affinity to SARS-CoV-2 Sgp and hACE-2, respectively compared to the standard drugs cefoperazone (CFZ) and MLN-4760. Furthermore, the outcome of the structural analysis of the two proteins upon binding of the inhibitors showed that the two proteins (SARS-CoV-2 Sgp and hACE-2) were stable, and the structural integrity of the proteins was not compromised. This study suggests pyrazolone-based compounds might be potent blockers of the viral entry into the host cells.
Synthesis, characterization, and in vitro microbial evaluation of some new 4H-chromene and quinoline derivatives of 1H-pyrazole
Thumar, Nilesh J.,Patel, Manish P.
, p. 1169 - 1178 (2013/01/15)
A new series of nine derivatives of 4H-pyrano[3,2-c]chromene and 12 derivatives of N-thiazolyl-4H-quinoline of 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde, malononitrile, and 4-hydroxy coumarin or β-enaminones, respectively. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR, 13C NMR spectral data and were further screened, against a panel of pathogenic strains of bacteria and fungi.
Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole
Sangani, Chetan B.,Mungra, Divyesh C.,Patel, Manish P.,Patel, Ranjan G.
scheme or table, p. 57 - 60 (2012/04/04)
A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde 1a-l, malononitrile 2 and 4-hydroxy-6-methylpyrone 3. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and antifungal activity against, two fungal pathogens, A. fumigatus and C. albicans using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs, against most of employed strains.
Synthesis and antimicrobial screening of pyrano[3,2-c]chromene derivatives of 1H-pyrazoles
Sangani, Chetan B.,Mungra, Divyesh C.,Patel, Manish P.,Patel, Ranjan G.
body text, p. 635 - 647 (2012/04/23)
A new series of twenty four derivatives of pyrano[3,2-c]chromene IVa-x bearing 1H-pyrazole were synthesized by a one pot, base-catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde Ia-l, malononitrile II and 4-hydroxycoumarin IIIa-b. All the synthesized compounds were characterized by elemental analysis, FT-IR, 1H NMR and 13C NMR spectral data. All the synthesized compounds were screened against six bacterial pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli and for antifungal activity against two fungal pathogens, A. fumigatus and C. albicans using the broth microdilution MIC method. Some of the compounds were found to be equipotent or more potent than commercial drugs against most of employed strains, as evident from the screening data. Versita Sp. z o.o.
Synthesis and antiviral activities of pyrazole derivatives containing an oxime moiety
Ouyang, Guiping,Cai, Xue-Jian,Chen, Zhuo,Song, Bao-An,Bhadury, Pinaki S.,Yang, Song,Jin, Lin-Hong,Xue, Wei,Hu, De-Yu,Zeng, Song
scheme or table, p. 10160 - 10167 (2010/04/05)
Target compounds 4a-n were obtained by the reaction of 1 -substituted phenyl-3-methyl-5-substituted phenylthio-4-pyrazolaldoximes (3) with chloromethylated heterocyclic compounds (CICH2-R3) under reflux conditions in ethanol. Subsequ
