Technology Process of 5'-O-[N-(3-carboxylatobenzoyl)sulfamoyl]cytidine sodium salt
There total 6 articles about 5'-O-[N-(3-carboxylatobenzoyl)sulfamoyl]cytidine sodium salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dicyclohexyl-carbodiimide / tetrahydrofuran / 2.5 h / 0 - 20 °C
2: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
3: trifluoroacetic acid / water; methanol / 2 h / 0 - 20 °C
4: sodium hydroxide / 10 h / 20 °C / pH 11.5
With
caesium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2012.12.017
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sulphamoyl chloride / 1,2-dimethoxyethane / 0 - 20 °C / Inert atmosphere
2: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
3: trifluoroacetic acid / water; methanol / 2 h / 0 - 20 °C
4: sodium hydroxide / 10 h / 20 °C / pH 11.5
With
sulphamoyl chloride; caesium carbonate; trifluoroacetic acid; sodium hydroxide;
In
methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2012.12.017
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C
2: trifluoroacetic acid / water; methanol / 2 h / 0 - 20 °C
3: sodium hydroxide / 10 h / 20 °C / pH 11.5
With
caesium carbonate; trifluoroacetic acid; sodium hydroxide;
In
methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.carres.2012.12.017
