isophthalic acid methyl ONSu ester

Base Information

• Chemical Name: isophthalic acid methyl ONSu ester
• CAS No.: 1334952-91-8
• Molecular Formula: C₁₃H₁₁NO₆
• Molecular Weight: 277.233
• Mol file: 1334952-91-8.mol

Synonyms:isophthalic acid methyl ONSu ester

Chemical Property of isophthalic acid methyl ONSu ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of isophthalic acid methyl ONSu ester

There total 1 articles about isophthalic acid methyl ONSu ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.4%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + benzene 1,3-dicarboxylic acid monomethyl ester (1877-71-0) → isophthalic acid methyl ONSu ester (1334952-91-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; for 19h; Inert atmosphere;

DOI:10.1002/anie.201102834

Reference yield: 36.0%

isophthalic acid methyl ONSu ester (1334952-91-8) + C36H61NO29 (121916-94-7) → C44H65NO32

Guidance literature:

isophthalic acid methyl ONSu ester; C₃₆H₆₁NO₂₉; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

With sodium hydroxide; In water; N,N-dimethyl-formamide; for 48h; Inert atmosphere;

With citric acid; In water; N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1002/anie.201102834

Reference yield:

isophthalic acid methyl ONSu ester (1334952-91-8) + N-acetyl-2',3'-isopropylidine-5'-O-sulfamoylcytidine (1452840-46-8) → C23H26N4O11S

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/j.carres.2012.12.017

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

benzene 1,3-dicarboxylic acid monomethyl ester

Downstream raw materials:

5'-O-[N-(3-methoxycarbonylbenzoyl)sulfamoyl]cytidine

5'-O-[N-(3-carboxylatobenzoyl)sulfamoyl]cytidine sodium salt