2-(2-(2-Chlorophenoxy)phenyl)acetic acid

Base Information

Chemical Name:2-(2-(2-Chlorophenoxy)phenyl)acetic acid
CAS No.:81682-40-8
Molecular Formula:C₁₄H₁₁ClO₃
Molecular Weight:262.693
Hs Code.:
ChEMBL ID:CHEMBL30038
DSSTox Substance ID:DTXSID601286461
Pharos Ligand ID:KDTPPAG2LYPZ

Synonyms:CHEMBL30038;2-(2-(2-chlorophenoxy)phenyl)acetic acid;DTXSID601286461;BDBM50295282;2-(2-Chlorophenoxy)benzeneacetic acid;81682-40-8;PD179682;[2-(2-Chloro-phenoxy)-phenyl]-acetic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-(2-Chlorophenoxy)phenyl)acetic acid

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:262.0396719
Heavy Atom Count:18
Complexity:282

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CC(=O)O)OC2=CC=CC=C2Cl

Technology Process of 2-(2-(2-Chlorophenoxy)phenyl)acetic acid

There total 6 articles about 2-(2-(2-Chlorophenoxy)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[2-(2-Chloro-phenoxy)-phenyl]-acetamide

: 81682-40-8
[2-(2-Chloro-phenoxy)-phenyl]-acetic acid

Guidance literature:: With sodium hydroxide; In 2-ethoxy-ethanol; for 16h; Heating;
DOI:10.1021/jm00364a004

Reference yield:

: 95-57-8
2-monochlorophenol

: 81682-40-8
[2-(2-Chloro-phenoxy)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) sodium ethoxide, 2.) copper / 1.) ethanol, 2.) 190 deg C, 3 h

2: thionyl chloride / 2 h / 100 °C

3: diethyl ether / Ambient temperature

4: AgNO₃, NH₄OH / dioxane; H₂O / 16 h / Heating

5: aq. NaOH / 2-ethoxy-ethanol / 16 h / Heating

With ammonium hydroxide; sodium hydroxide; thionyl chloride; sodium ethanolate; copper; silver nitrate; In 1,4-dioxane; 2-ethoxy-ethanol; diethyl ether; water;
DOI:10.1021/jm00364a004

Reference yield:

: 40501-39-1
o-(o'-Chlorphenoxy)benzoylchlorid

: 81682-40-8
[2-(2-Chloro-phenoxy)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: diethyl ether / Ambient temperature

2: AgNO₃, NH₄OH / dioxane; H₂O / 16 h / Heating

3: aq. NaOH / 2-ethoxy-ethanol / 16 h / Heating

With ammonium hydroxide; sodium hydroxide; silver nitrate; In 1,4-dioxane; 2-ethoxy-ethanol; diethyl ether; water;
DOI:10.1021/jm00364a004