4-benzyl-1-isopropyl-2-hydroxysuccinate

Base Information

• Chemical Name: 4-benzyl-1-isopropyl-2-hydroxysuccinate
• CAS No.: 1236311-07-1
• Molecular Formula: C₁₄H₁₈O₅
• Molecular Weight: 266.294
• Mol file: 1236311-07-1.mol

Synonyms:

Chemical Property of 4-benzyl-1-isopropyl-2-hydroxysuccinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyl-1-isopropyl-2-hydroxysuccinate

There total 2 articles about 4-benzyl-1-isopropyl-2-hydroxysuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

isopropyl alcohol (67-63-0,8013-70-5) + (S)-4-(benzyloxy)-2-hydroxy-4-oxobutanoic acid → 4-benzyl-1-isopropyl-2-hydroxysuccinate (1236311-07-1)

Guidance literature:

With toluene-4-sulfonic acid; Reflux; Molecular sieve;

DOI:10.1021/bm1004355

Reference yield:

2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester (242810-01-1) → 4-benzyl-1-isopropyl-2-hydroxysuccinate (1236311-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: water; acetic acid / tetrahydrofuran / 24 h / 40 °C

2: toluene-4-sulfonic acid / Reflux; Molecular sieve

With water; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran;

DOI:10.1021/bm1004355

Reference yield: 76.0%

4-benzyl-1-isopropyl-2-hydroxysuccinate (1236311-07-1) + acetyl chloride (75-36-5) → 4-benzyl-1-isopropyl-2-acetoxysuccinate (1236311-09-3)

Guidance literature:

at 20 ℃; for 2h;

DOI:10.1021/bm1004355

upstream raw materials:

2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester

isopropyl alcohol

Downstream raw materials:

4-benzyl-1-isopropyl-2-acetoxysuccinate