2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester

Base Information

• Chemical Name: 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester
• CAS No.: 242810-01-1
• Molecular Formula: C₁₄H₁₆O₅
• Molecular Weight: 264.278
• Mol file: 242810-01-1.mol

Synonyms:2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester

Chemical Property of 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester

There total 4 articles about 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl bromide (100-39-0) + 2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid (113278-68-5,114458-03-6,119618-59-6,73991-95-4) → 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester (242810-01-1)

Guidance literature:

With triethylamine; In acetone; for 60h; Reflux; Inert atmosphere;

DOI:10.1021/bm1004355

Reference yield: 78.0%

2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid (113278-68-5,114458-03-6,119618-59-6,73991-95-4) + benzyl alcohol (100-51-6,185532-71-2) → 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester (242810-01-1)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 15h; Inert atmosphere;

DOI:10.1016/j.bioorg.2018.08.016

Reference yield: 69.98%

benzyl chloride (100-44-7) + 2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid (113278-68-5,114458-03-6,119618-59-6,73991-95-4) → 2-[2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid benzyl ester (242810-01-1)

Guidance literature:

With triethylamine; In acetone; Reflux;

upstream raw materials:

benzyl bromide

2-[(4S)-2,2-dimethyl-5-oxo-1,3-dioxolan-4-yl]acetic acid

2,2-dimethoxy-propane

benzyl alcohol

Downstream raw materials:

2-(2-bromoacetoxy)succinic acid 4-benzyl ester

3(S)-[(benzyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione

3,6-(S)-[di(benzyloxycarbonyl)methyl]-1,4-dioxane-2,5-dione

4-benzyl-1-isopropyl-2-hydroxysuccinate