(R)-1-acetoxy-3-benzoyloxypropan-2-ol

Base Information

• Chemical Name: (R)-1-acetoxy-3-benzoyloxypropan-2-ol
• CAS No.: 256462-86-9
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.24
• Mol file: 256462-86-9.mol

Synonyms:

Chemical Property of (R)-1-acetoxy-3-benzoyloxypropan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-1-acetoxy-3-benzoyloxypropan-2-ol

There total 3 articles about (R)-1-acetoxy-3-benzoyloxypropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Benzoyloxy-3-hydroxy-2-propanone (29751-66-4) → (R)-1-acetoxy-3-benzoyloxypropan-2-ol (256462-86-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N; DMAP / ethyl acetate / 1.5 h / 20 °C

2: baker's yeast; glucose / aq. phosphate buffer; ethanol; dimethylsulfoxide / 3 h / pH 7

With dmap; baker's yeast; D-glucose; triethylamine; In phosphate buffer; ethanol; dimethyl sulfoxide; ethyl acetate; 1: Acetylation / 2: Reduction;

DOI:10.1016/S0957-4166(99)00415-2

Reference yield:

benzoyl chloride (98-88-4) → (R)-1-acetoxy-3-benzoyloxypropan-2-ol (256462-86-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / DMAP; pyridine

2: 75 percent / Et₃N; DMAP / ethyl acetate / 1.5 h / 20 °C

3: baker's yeast; glucose / aq. phosphate buffer; ethanol; dimethylsulfoxide / 3 h / pH 7

With pyridine; dmap; baker's yeast; D-glucose; triethylamine; In phosphate buffer; ethanol; dimethyl sulfoxide; ethyl acetate; 1: Esterification / 2: Acetylation / 3: Reduction;

DOI:10.1016/S0957-4166(99)00415-2

Reference yield:

1-acetoxy-3-benzyloxypropan-2-one (256462-82-5) → (R)-1-acetoxy-3-benzoyloxypropan-2-ol (256462-86-9) + Benzoic acid (S)-3-acetoxy-2-hydroxy-propyl ester

Guidance literature:

With baker's yeast; D-glucose; In phosphate buffer; ethanol; dimethyl sulfoxide; for 3h; pH=7; Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(99)00415-2

upstream raw materials:

1-acetoxy-3-benzyloxypropan-2-one

1-Benzoyloxy-3-hydroxy-2-propanone

benzoyl chloride