29751-66-4Relevant academic research and scientific papers
Synthesis of α-Acyloxy-α′-hydroxy Ketones via Cyclic Carbonate Intermediates Generated from Tertiary Bromopropargylic Alcohols and Cs2CO3
Shemyakina, Olesya A.,Volostnykh, Ol'ga G.,Stepanov, Anton V.,Ushakov, Igor' A.
supporting information, p. 7117 - 7121 (2019/11/16)
A facile approach towards α-acyloxy-α′-hydroxy ketones by reaction of readily available tertiary bromopropargylic alcohols and carboxylic acids in system Cs2CO3/H2O/DMF (50–55 °C, 4 h) was developed. Key intermediates of this synthesis are cyclic carbonates generated in situ from bromopropargylic alcohols and Cs2CO3 which have been utilized as both reagent and base promoter.
Benzimidazole compound
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Page/Page column 68-69, (2008/06/13)
An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.
Microbial asymmetric reduction of α-hydroxyketones in the anti-Prelog selectivity
Tsujigami, Toshikuni,Sugai, Takeshi,Ohta, Hiromichi
, p. 2543 - 2549 (2007/10/03)
Yamadazyma farinosa IFO 10896 was found to reduce α-hydroxyketones bearing a phenyl ring to give optically active diols with anti-Prelog selectivity. The distance between the carbonyl group and the phenyl ring was shown to have an interesting effect on the reactivity and selectivity of the enzyme system.
Baker's yeast mediated reduction of dihydroxyacetone derivatives
Balint, Jozsef,Egri, Gabriella,Kolbert, Attila,Dianoczky, Csilla,Fogassy, Elemer,Novak, Lajos,Poppe, Laszlo
, p. 4017 - 4028 (2007/10/03)
Several monoprotected dihydroxyacetone derivatives 4a-d and their acetates 5a-d were prepared and subjected to biotransformation with baker's yeast. The simple chemical modification of the substrates (i.e. transforming the relatively small hydrophilic hyd
Macrocyclic polyesters. I. A novel class of 1,3-butandiol derivatives as potential antimicrobial agents
Fadda,Maccioni,Maccioni,Podda
, p. 99 - 110 (2007/10/02)
This paper reports the synthesis of a novel class of macrocyclic tetraesters containing 1,3-butandiol sub-units by reacting the stannolan derivative of the diol with diacyl chloride. The structure of the possible isomers was assigned by spectroscopic data
Enatioselective Microbial Reduction of Monoesters of 1,3-Dihydroxypropanone: Synthesis of (S)- and (R)-1,2-O-Isopropylideneglycerol
Aragozzini, Fabrizio,Maconi, Elisabetta,Potenza, Donatella,Scolastico, Carlo
, p. 225 - 227 (2007/10/02)
The reduction of 3-benzoyloxy-1-hydroxypropanone with bakers' yeast proceeds enantioselectively to afford (S)-3-benzoyloxy-1,2-propanediol, which may be further converted into (S)-(benzoyloxymethyl)oxirane.The bioreduction with fermenting yeast of 1-acetoxy-3-benzyloxypropanones gives (R)-1-benzyloxy-3-acetoxy-2-propanol which can be used for the preparation of both (S)- and (R)-1,2-O-isopropylideneglycerol.
