1H-Indole-2,3-dione, 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-, 3-[[4-(trifluoromethyl)phenyl]hydrazone]

Base Information

Chemical Name:1H-Indole-2,3-dione, 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-, 3-[[4-(trifluoromethyl)phenyl]hydrazone]
CAS No.:128231-51-6
Molecular Formula:C₁₉H₁₄F₃N₅O₂S
Molecular Weight:433.414
Hs Code.:
Mol file:128231-51-6.mol

Synonyms:

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Chemical Property of 1H-Indole-2,3-dione, 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-, 3-[[4-(trifluoromethyl)phenyl]hydrazone]

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Technology Process of 1H-Indole-2,3-dione, 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-, 3-[[4-(trifluoromethyl)phenyl]hydrazone]

There total 4 articles about 1H-Indole-2,3-dione, 5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-, 3-[[4-(trifluoromethyl)phenyl]hydrazone] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 455-14-1
4-trifluoromethylphenylamine

: 128231-54-9
1,3-dihydro-5-(3,6-dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-2H-indol-2-one

: 128231-41-4,128231-51-6,128253-04-3
5-(3,6-Dihydro-6-methyl-2-oxo-2H-1,3,4-thiadiazin-5-yl)-1H-indole-2,3-dione 3-[4-trifluoromethylphenylhydrazone]

Guidance literature:: With hydrogenchloride; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 59-48-3
2-oxoindole

: 128231-41-4,128231-51-6,128253-04-3
5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-1H-indol-2,3-dione 3-<4-trifluoromethylphenylhydrazone>

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / AlCl₃ / dimethylformamide / 1) RT, 18h, 2) 40 deg C, 1h

2: 87 percent / TFA / acetonitrile / 6.5 h / Heating

3: 1) NaNO₂, conc. HCl / 1) H₂O 0 to 5 deg C, 2) DMF, EtOH, 1h, RT

With hydrogenchloride; aluminium trichloride; trifluoroacetic acid; sodium nitrite; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570280609

Reference yield:

: 65435-05-4
5-<(2-bromo-1-oxo)propyl>-1,3-dihydro-2H-indol-2-one

: 128231-41-4,128231-51-6,128253-04-3
5-(3,6-dihydro-6-methyl-2-oxo-1,3,4-thiadiazin-5-yl)-1H-indol-2,3-dione 3-<4-trifluoromethylphenylhydrazone>

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / TFA / acetonitrile / 6.5 h / Heating

2: 1) NaNO₂, conc. HCl / 1) H₂O 0 to 5 deg C, 2) DMF, EtOH, 1h, RT

With hydrogenchloride; trifluoroacetic acid; sodium nitrite; In acetonitrile;
DOI:10.1002/jhet.5570280609