C₁₈H₁₂ClF₂N₃O₃S

Base Information

Chemical Name:C₁₈H₁₂ClF₂N₃O₃S
CAS No.:1422828-33-8
Molecular Formula:C₁₈H₁₂ClF₂N₃O₃S
Molecular Weight:423.827
Hs Code.:

C<sub>18</sub>H<sub>12</sub>ClF<sub>2</sub>N<sub>3</sub>O<sub>3</sub>S

Synonyms:

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Chemical Property of C₁₈H₁₂ClF₂N₃O₃S

Chemical Property:

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Technology Process of C₁₈H₁₂ClF₂N₃O₃S

There total 5 articles about C₁₈H₁₂ClF₂N₃O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13036-57-2
2-chloro-4-methylpyrimidine

: 1422828-32-7
C₁₄H₁₁F₂NO₄S

: 1422828-33-8
C₁₈H₁₂ClF₂N₃O₃S

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h; Cooling with ice;
DOI:10.1021/ml4000063

Reference yield:

: 1007-16-5
3-bromo-4-fluorobenzoic acid

: 1422828-33-8
C₁₈H₁₂ClF₂N₃O₃S

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 1 h / Reflux

2: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

4: pyridine / dichloromethane / 20 °C

5: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; sulfuric acid; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml4000063

Reference yield:

: 82702-31-6
methyl 3-bromo-4-fluorobenzoate

: 1422828-33-8
C₁₈H₁₂ClF₂N₃O₃S

Guidance literature:: Multi-step reaction with 4 steps

1: tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 90 °C / Sealed tube; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: pyridine / dichloromethane / 20 °C

4: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

With pyridine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ml4000063