C₂₄H₃₇FO₅

Base Information

• Chemical Name: C₂₄H₃₇FO₅
• CAS No.: 117169-34-3
• Molecular Formula: C₂₄H₃₇FO₅
• Molecular Weight: 424.553
• Mol file: 117169-34-3.mol

Synonyms:

Chemical Property of C₂₄H₃₇FO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₃₇FO₅

There total 8 articles about C₂₄H₃₇FO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,5-(1,2-Ethanediyldioxy)-1-exo-<3-(1-fluorocyclohexyl)-3-oxo-(E)-1-propenyl>-2-endo-(tetrahydropyran-2-yloxy)octahydropentalene (117189-39-6) → C24H37FO5 (117169-34-3,117248-66-5)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 0.166667h; Yield given; Ambient temperature;

DOI:10.1055/s-1988-27551

Reference yield:

1-oxaspiro<2,5>octane-2-carboxylic acid nitrile (36929-66-5,500899-63-8,500899-64-9) → C24H37FO5 (117169-34-3,117248-66-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 86 percent / 70percent HF / CH₂Cl₂; pyridine / 1.) 0 deg C, 1 h, 2.) room temp., 1 h

2: 74 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / 0 °C

3: 59 percent / Jones reagent / acetone / 0 °C

4: 79 percent / diethyl ether / 5 °C

5: 1.) BuLi / 1.) hexane, THF, -70 deg C, 15 min, 2.) -70 deg C, 1 h; room temp., 1 h

6: 1.) NaH / 1.) THF, 30 min, 2.) -40 deg C, 1 h; room temp., 1 h

7: NaBH₄ / methanol / 0.17 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; jones reagent; hydrogen fluoride; sodium hydride; In pyridine; methanol; diethyl ether; dichloromethane; water; isopropyl alcohol; acetone;

DOI:10.1055/s-1988-27551

Reference yield:

α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile (699-43-4) → C24H37FO5 (117169-34-3,117248-66-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 74 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / 0 °C

2: 59 percent / Jones reagent / acetone / 0 °C

3: 79 percent / diethyl ether / 5 °C

4: 1.) BuLi / 1.) hexane, THF, -70 deg C, 15 min, 2.) -70 deg C, 1 h; room temp., 1 h

5: 1.) NaH / 1.) THF, 30 min, 2.) -40 deg C, 1 h; room temp., 1 h

6: NaBH₄ / methanol / 0.17 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; jones reagent; sodium hydride; In methanol; diethyl ether; water; isopropyl alcohol; acetone;

DOI:10.1055/s-1988-27551

upstream raw materials:

5,5-(1,2-Ethanediyldioxy)-1-exo-<3-(1-fluorocyclohexyl)-3-oxo-(E)-1-propenyl>-2-endo-(tetrahydropyran-2-yloxy)octahydropentalene

1-oxaspiro<2,5>octane-2-carboxylic acid nitrile

α-(1-Fluorocyclohexyl)-α-hydroxyacetonitrile

cyclohexanone

Downstream raw materials:

<(5E,Z),(13E)>-15-(1-Fluorocyclohexyl)-11α,(15R)-dihydroxy-ω-pentanor-9a-carbaprostacyclin

<(5E,Z),(13E)>-15-(1-Fluorocyclohexyl)-11α,(15S)-dihydroxy-ω-pentanor-9a-carbaprostacyclin

1-exo-<3-(1-Fluorocyclohexyl)-3(S)-hydroxy-(E)-1-propenyl>-2-endo-hydroxy-5-oxooctahydropentalene

1-exo-<3-(1-Fluorocyclohexyl)-3(R)-hydroxy-(E)-1-propenyl>-2-endo-hydroxy-5-oxooctahydropentalene