N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester

Base Information

• Chemical Name: N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester
• CAS No.: 928330-08-9
• Molecular Formula: C₂₃H₂₉FN₄O₆S
• Molecular Weight: 508.571
• Mol file: 928330-08-9.mol

Synonyms:

Chemical Property of N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester

There total 4 articles about N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(4-fluorophenyl)ethylamine (374898-01-8) → N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester (928330-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / EDC; HOAt / CHCl₃ / 50 h / 20 °C

2: aq. LiOH / tetrahydrofuran / 5 h / 20 °C

3: HOAt; EDC / dimethylformamide / 5 h

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm061046r

Reference yield:

N-[1-(4-fluoro-phenyl)-ethyl]-5-(methanesulfonyl-methyl-amino)-isophthalamic acid methyl ester (827579-70-4) → N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester (928330-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran / 5 h / 20 °C

2: HOAt; EDC / dimethylformamide / 5 h

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm061046r

Reference yield:

3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid (695215-94-2) → N'-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-benzoyl]-hydrazinecarboxylic acid tert-butyl ester (928330-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / EDC; HOAt / CHCl₃ / 50 h / 20 °C

2: aq. LiOH / tetrahydrofuran / 5 h / 20 °C

3: HOAt; EDC / dimethylformamide / 5 h

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/jm061046r

upstream raw materials:

t-butoxycarbonylhydrazine

3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

(R)-1-(4-fluorophenyl)ethylamine

3-(methoxycarbonyl)-5-[methyl(methylsulfonyl)amino]benzoic acid

Downstream raw materials:

(1-{5-[3-[1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-(methanesulfonyl-methyl-amino)-phenyl]-[1,3,4]oxadiazol-2-yl}-1-methyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester

N-[(1R)-1-(4-fluorophenyl)ethyl]-3-(hydrazinocarbonyl)-5-[methyl(methylsulfonyl)amino]benzamide