(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

Base Information

Chemical Name:(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester
CAS No.:69025-95-2
Molecular Formula:C₂₉H₃₅F₃O₇S
Molecular Weight:584.654
Hs Code.:

(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzo<b,d>pyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

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Chemical Property of (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

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Technology Process of (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

There total 8 articles about (+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 63790-11-4,129706-35-0,129706-40-7
(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-ol

: 29540-81-6
1-(trifluoromethylsulfonyl)-1H-imidazole

: 69025-95-2,129706-39-4,129706-45-2
(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

Guidance literature:: With sodium hydride; at 80 ℃; for 2h;
DOI:10.1002/jhet.5570270312

Reference yield:

: 883-09-0
5,7-dihydroxy-2,2-dimethylchroman-4-one

: 69025-95-2,129706-39-4,129706-45-2
(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 80 °C

2: NaH / diethyl ether / 18 h

3: Et₃N / methanol / 20 h / 25 °C

4: 54 percent / KOH / ethanol / 18 h / Heating

5: 76 percent / Li, liq. NH₃ / tetrahydrofuran / -78 °C

6: 100 percent / p-toluenesulfonic acid*H₂O / benzene / 1 h / Heating

7: 93 percent / NaH / 2 h / 80 °C

With potassium hydroxide; ammonia; lithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jhet.5570270312

Reference yield:

: 63790-07-8
1-methyl-4-phenylbutyl methanesulphonate

: 69025-95-2,129706-39-4,129706-45-2
(+/-)-6,6aβ,7,8,10,10aα-hexahydro-6,6-dimethyl-3-(1-methyl-4-phenylbutoxy)spiro<9H-dibenzopyran-9,2'-<1,3>dioxolan>-1-yl trifluoromethanesulfonic acid ester

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 80 °C

2: NaH / diethyl ether / 18 h

3: Et₃N / methanol / 20 h / 25 °C

4: 54 percent / KOH / ethanol / 18 h / Heating

5: 76 percent / Li, liq. NH₃ / tetrahydrofuran / -78 °C

6: 100 percent / p-toluenesulfonic acid*H₂O / benzene / 1 h / Heating

7: 93 percent / NaH / 2 h / 80 °C

With potassium hydroxide; ammonia; lithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1002/jhet.5570270312