883-09-0

Basic information

• Product Name: 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one
• Synonyms: 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one;4H-1-BENZOPYRAN-4-ONE,2,3-DIHYDRO-5,7-DIHYDROXY-2,2-DIMETHYL-;OTAVA-BB 1090423
• CAS NO: 883-09-0
• Molecular Formula: C₁₁H₁₂O₄
• Molecular Weight: 208.21
• Mol File: 883-09-0.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 404.3°C at 760 mmHg
• Flash Point: 162.7°C
• Appearance: /
• Density: 1.308g/cm³
• Vapor Pressure: 4.08E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one(883-09-0)
• EPA Substance Registry System: 5,7-dihydroxy-2,2-dimethyl-2,3-dihydro-4H-chromen-4-one(883-09-0)

Safety Data

• Hazardous Substances Data: 883-09-0(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 545, 1985 DOI: 10.1055/s-1985-31270

InChI:InChI=1/C11H12O4/c1-11(2)5-8(14)10-7(13)3-6(12)4-9(10)15-11/h3-4,12-13H,5H2,1-2H3

Upstream product

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Downstream Products

• 50386-14-6 7-benzyloxy-2,2-dimethyl-5-hydroxy-4-chromanone 
• 21421-64-7 5,7-dihydroxy-2,2-dimethyl-chroman-4-one-(2,4-dinitro-phenylhydrazone) 
• 63789-85-5 2,3-dihydro-2,2-dimethyl-5-hydroxy-7-(1-methyl-4-phenylbutoxy)-4H-1-benzopyran-4-one 
• 888027-28-9 [(4,8,8-trimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-5-yl)oxy]acetic acid 
• 4236-32-2 2,2-dimethyl-5-hydroxy-4-keto-benzopyran 
• 94244-81-2 7-Isopropoxy-5-methoxy-2,2-dimethyl-2H-chromene 
• 117902-87-1 5-Methoxy-2,2-dimethyl-7-prop-2-ynyloxy-2H-chromene 
• 94244-83-4 5-methoxy-7-isobutoxy-2,2-dimethyl-2H-chromene 
• 136135-88-1 4-[7-Butoxy-5-hydroxy-2,2-dimethyl-chroman-(4E)-ylideneamino]-butyric acid benzyl ester 
• 100669-27-0 6-benzoyl-2,2-dimethyl-5-hydroxy-7-pentoxy-4-chromanone 
• 100669-35-0 2-phenyl-1,4-dihydro-4,4-dimethyl-9-hydroxy-7-pentoxy<1>benzopyrano<4,3-c>pyrazole 
• 100669-37-2 2,2-dimethyl-3-(phenylhydrazonomethylidene)-5-hydroxy-7-pentoxy-4-chromanone 
• 859134-29-5 [(2,2-dimethyl-6-oxo-3,4,6,7,8,9-hexahydrocyclopenta[c]pyrano[2,3-h]chromen-10-yl)oxy]acetic acid 

Relevant articles and documents

Drug efficacy of novel 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans; evaluated via DNA gyrase inhibition, bacterial cell wall lesion and antibacterial prospective

In this study, novel 3-O-methoxy-4-halo, disubstituted-5,7-dimethoxy chromans with bacterial cell wall degrading potentials were synthesized, characterized and evaluated as DNA gyrase inhibitors and antibacterial agents. Compounds were showed a broad spectrum of antimicrobial activity against both Gram+ve bacteria (S. aureus (MTCC 3160), C. diphtheriae (MTCC 116), S. pyogenes (MTCC 442)) and Gram?ve bacteria (E. coli (MTCC 443), P. aeruginosa (MTCC 424), K. pneumoniae (MTCC 530)). Further, a molecular docking study was carried out to get more insight into the binding mode of present study compounds to target proteins (PDB ID: 2XCT (S. aureus DNA gyrase A), PDB ID: 3G75 (S. aureus DNA gyrase B), PDB ID: 3L7L (Teichoic acid polymerase). In the results, 14 > 20 > 24 > 12 > 18 > 17 were found as the most active against almost all executed activities in this study. The predicted Lipinski's filter scores, SAR, pharmacokinetic/pharmacodynamics, and ADMET properties of these compounds envisioned the druggability prospects and the necessity of further animal model evaluations of 3-O-methoxy-4-halo disubstituted 5,7-dimethoxy chromans to establish them as an effective and future antibiotics.

Heterocyclic-fused benzopyrans as cannabinoid analogues

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USE OF CHROMAN-4-ONE DERIVATIVES

The invention relates to the use of compounds of the formula (I) or of a composition comprising at least one compound of the formula (I), containing radicals as described in the claims, for the care, preservation or improvement of the general state of the skin or hair.

Indole derivative having piperidine ring

The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. It is an object of the present invention to discover an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage, which has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor.