(2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE

Base Information

• Chemical Name: (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE
• CAS No.: 128899-30-9
• Molecular Formula: C₁₁H₂₃NO₂Si
• Molecular Weight: 229.395
• Hs Code.: 2933790090
• Mol file: 128899-30-9.mol

Synonyms:5(R)-5-{(tert-Butyldimethylsilyloxy)methyl}pyrrolidin-2-one;

Chemical Property of (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE

Chemical Property:

• PSA: 38.33000
• LogP: 2.61560
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

(R)-5-(((tert-Butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE

There total 9 articles about (2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-5-hydroxymethylpyrrolidin-2-one (66673-40-3) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one (128899-30-9,100548-49-0,106191-02-0)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2013.02.014

Reference yield: 24.0%

tert-butyldimethylsilyl chloride (18162-48-6) + D-pyrrolidone-5-carboxylic acid (4042-36-8) → (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one (128899-30-9,100548-49-0,106191-02-0)

Guidance literature:

D-pyrrolidone-5-carboxylic acid; With thionyl chloride; In methanol; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 16h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

C5H7NO2 (96914-00-0) + tert-butyldimethylsilyl chloride (18162-48-6) → (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one (128899-30-9,100548-49-0,106191-02-0)

Guidance literature:

With 1H-imidazole; In methanol; N,N-dimethyl-formamide; at 20 ℃; for 16h;

upstream raw materials:

(R)-5-hydroxymethylpyrrolidin-2-one

tert-butyldimethylsilyl chloride

D-Glutamic acid

methyl (2R)-pyroglutamate

Downstream raw materials:

tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate

5-{3-[2-oxo-5-(3-oxo-4-phenyl-but-1-enyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester

5-{3-[2-oxo-5S-(3-oxo-4-phenyl-butyl)-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester

5-{3-[2S-(3-hydroxy-4-phenyl-butyl)-5-oxo-pyrrolidin-1-yl]-propyl}-thiophene-2-carboxylic acid methyl ester