C₁₅H₁₅NO₄

Base Information

• Chemical Name: C₁₅H₁₅NO₄
• CAS No.: 1429297-51-7
• Molecular Formula: C₁₅H₁₅NO₄
• Molecular Weight: 273.288
• Mol file: 1429297-51-7.mol

Synonyms:

Chemical Property of C₁₅H₁₅NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₅NO₄

There total 2 articles about C₁₅H₁₅NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + C14H13NO4 → C15H15NO4 (1429297-51-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 55 ℃;

DOI:10.1016/j.bmcl.2013.02.037

Reference yield:

5-bromo-2-methoxy-nicotinic acid (54916-66-4) + benzyl alcohol (100-51-6,185532-71-2) → C15H15NO4 (1429297-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; 1,10-Phenanthroline; caesium carbonate / toluene / 110 °C

2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 0 - 55 °C

With copper(l) iodide; 1,10-Phenanthroline; oxalyl dichloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2013.02.037

Reference yield:

C15H15NO4 (1429297-51-7) → C23H19Cl2FN4O3 (1429297-57-3)

Guidance literature:

Multi-step reaction with 6 steps

1: palladium on activated charcoal; hydrogen / methanol

2: di-isopropyl azodicarboxylate; triphenylphosphine / toluene / 0 - 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / -5 - 0 °C

4: Dess-Martin periodane; sodium hydrogencarbonate / dichloromethane / 20 °C

5: sodium hydrogensulfite / water; ethanol / Reflux

6: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; Dess-Martin periodane; sodium hydrogensulfite; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.bmcl.2013.02.037

upstream raw materials:

5-bromo-2-methoxy-nicotinic acid

benzyl alcohol

methanol

Downstream raw materials:

C₂₃H₁₉Cl₂FN₄O₃

C₂₆H₂₆Cl₂FN₅O₃

C₂₈H₂₈Cl₂FN₅O₄

C₂₂H₁₇Cl₂FN₄O₃