Technology Process of (1R,6R,8R,9R)-4-Methyl-9-(tetrahydro-pyran-2-yloxy)-2-(toluene-4-sulfonyl)-5-oxa-2-aza-tricyclo[4.3.1.03,8]decan-6-ol
There total 12 articles about (1R,6R,8R,9R)-4-Methyl-9-(tetrahydro-pyran-2-yloxy)-2-(toluene-4-sulfonyl)-5-oxa-2-aza-tricyclo[4.3.1.03,8]decan-6-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: TsOH / CH2Cl2 / 0 °C
2: DIBAL / CH2Cl2 / 0 °C
3: t-BuOK / dimethylsulfoxide
4: (COCl)2, DMSO
5: I2, H2O / dimethylsulfoxide
6: 97 percent / Bu3SnH, azoisobutyronitrile / toluene / Heating
7: DIBAL / CH2Cl2
8: (COCl)2, DMSO
9: 81 percent / tetrahydrofuran / -30 °C
With
oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; iodine; tri-n-butyl-tin hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1039/c39900001412
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 80 percent / toluene / Heating
2: 89 percent / m-chloroperoxybenzoic acid (m-CPBA) / CH2Cl2 / Heating
3: 92 percent / benzene; CH2Cl2 / Heating
4: TsOH / CH2Cl2 / 0 °C
5: DIBAL / CH2Cl2 / 0 °C
6: t-BuOK / dimethylsulfoxide
7: (COCl)2, DMSO
8: I2, H2O / dimethylsulfoxide
9: 97 percent / Bu3SnH, azoisobutyronitrile / toluene / Heating
10: DIBAL / CH2Cl2
11: (COCl)2, DMSO
12: 81 percent / tetrahydrofuran / -30 °C
With
oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; iodine; tri-n-butyl-tin hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1039/c39900001412
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 92 percent / benzene; CH2Cl2 / Heating
2: TsOH / CH2Cl2 / 0 °C
3: DIBAL / CH2Cl2 / 0 °C
4: t-BuOK / dimethylsulfoxide
5: (COCl)2, DMSO
6: I2, H2O / dimethylsulfoxide
7: 97 percent / Bu3SnH, azoisobutyronitrile / toluene / Heating
8: DIBAL / CH2Cl2
9: (COCl)2, DMSO
10: 81 percent / tetrahydrofuran / -30 °C
With
oxalyl dichloride; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; water; iodine; tri-n-butyl-tin hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide;
In
tetrahydrofuran; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1039/c39900001412
