(3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester

Base Information

• Chemical Name: (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester
• CAS No.: 193086-12-3
• Molecular Formula: C₃₇H₅₀N₄O₆S
• Molecular Weight: 678.893
• Mol file: 193086-12-3.mol

Synonyms:

Chemical Property of (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester

There total 5 articles about (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-tert-butyl methyl(1-oxo-3-phenylpropan-2-yl)carbamate (181646-92-4) → (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester (193086-12-3)

Guidance literature:

Multi-step reaction with 5 steps

1: NaCNBH₃, HOAc

2: H₂ / Pd(OH)2

3: Et₃N / CH₂Cl₂ / -78 °C

4: TFA

5: 1.) EDAC, HOAt, 2.) 50 percent TFA, 3.) EDAC, HOAt

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; palladium dihydroxide; In dichloromethane;

DOI:10.1016/S0960-894X(99)00167-5

Reference yield:

N-((1R)-1-(hydroxymethyl)-2-phenylethyl)-N-methylcarbamic acid tert-butylester (181646-55-9) → (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester (193086-12-3)

Guidance literature:

Multi-step reaction with 6 steps

1: Et₃N, pyridine*SO₃

2: NaCNBH₃, HOAc

3: H₂ / Pd(OH)2

4: Et₃N / CH₂Cl₂ / -78 °C

5: TFA

6: 1.) EDAC, HOAt, 2.) 50 percent TFA, 3.) EDAC, HOAt

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sulfur trioxide pyridine complex; sodium cyanoborohydride; acetic acid; triethylamine; trifluoroacetic acid; palladium dihydroxide; In dichloromethane;

DOI:10.1016/S0960-894X(99)00167-5

Reference yield:

N-((1R)-1-benzyl-2-(benzylamino)ethyl)-N-methylcarbamic acid tert-butylester (193086-06-5) → (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester (193086-12-3)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pd(OH)2

2: Et₃N / CH₂Cl₂ / -78 °C

3: TFA

4: 1.) EDAC, HOAt, 2.) 50 percent TFA, 3.) EDAC, HOAt

With 1-hydroxy-7-aza-benzotriazole; hydrogen; triethylamine; trifluoroacetic acid; palladium dihydroxide; In dichloromethane;

DOI:10.1016/S0960-894X(99)00167-5

upstream raw materials:

(2R)-2-(N-(tert-butoxycarbonyl)-N-methylamino)-3-(2-naphthyl)-propionic acid

(2E)-5-(tert-butyloxycarbonylamino)-5-methylhex-2-enoic acid

N-((2R)-2-methylamino-3-phenylpropyl)methansulfonamide

(R)-tert-butyl methyl(1-oxo-3-phenylpropan-2-yl)carbamate