181646-92-4

Upstream product

• 181646-55-9 N-((1R)-1-(hydroxymethyl)-2-phenylethyl)-N-methylcarbamic acid tert-butylester 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 193086-06-5 N-((1R)-1-benzyl-2-(benzylamino)ethyl)-N-methylcarbamic acid tert-butylester 
• 193086-09-8 N-((2R)-2-methylamino-3-phenylpropyl)methansulfonamide 
• 193086-08-7 N-((1R)-1-benzyl-2-((methylsulfonyl)amino)ethyl)-N-methylcarbamic acid tert-butylester 
• 193086-12-3 (3E)-4-(N-((1R)-1-(N-((1R)-1-benzyl-2-(methylsulfonylamino)ethyl)-N-methylcarbamoyl)-2-(2-naphthyl)ethyl)-N-methylcarbamoyl)-1,1-dimethylbut-3-enylcarbamic acid tert-butyl ester 
• 1262432-89-2 (-)-(3S,4R)-4-(tert-butoxycarbonyl(methyl)amino)-3-hydroxy-N-methyl-N-((R,R)-2-phenyl-2-hydroxy-1-methylethyl)-5-phenylpentanamide 
• 1262432-94-9 (+)-(3S,4R)-4-(tert-butoxycarbonyl(methyl)amino)-3-hydroxy-5-phenylpentanoic acid methyl ester 

Relevant academic research and scientific papers

Compounds with growth hormone releasing properties

The present invention relates to compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.

Compounds with growth hormone releasing properties

There are disclosed novel synthetic peptides of formula (I) where A, B, D, E, F, G, J, m, n, and p are defined in the specification. Compounds of formula (I) promote the release of growth hormone in humans and animals. Growth promoting compositions containing such compounds of formula (I) as the active ingredient, methods of stimulating the release of growth hormone, and the use of such compounds of formula (I) are also disclosed.

New growth hormone secretagogues: C-terminal modified sulfonamide- analogues of NN703

The C-terminal the orally active growth hormone secretagogue NN703 was changed to prepare analogues with inverse sulfonamides and inverse amides. The compounds showed high activity in a in vitro rat pituitary model.