alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate

Base Information

• Chemical Name: alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate
• CAS No.: 146864-65-5
• Molecular Formula: C₁₇H₂₂Cl₃NO₁₁
• Molecular Weight: 522.721
• DSSTox Substance ID: DTXSID901117831
• Nikkaji Number: J2.346.622H
• Mol file: 146864-65-5.mol

Synonyms:DTXSID901117831;146864-65-5;alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate

Chemical Property of alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 12
• Exact Mass: 521.025844
• Heavy Atom Count: 32
• Complexity: 727

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)OCC1C(C(C(C(O1)OC(=O)C)NC(=O)OCC(Cl)(Cl)Cl)OC(=O)C)OC(=O)C
• Isomeric SMILES: CC(=O)OC[C@@H]1[C@@H]([C@@H]([C@H]([C@H](O1)OC(=O)C)NC(=O)OCC(Cl)(Cl)Cl)OC(=O)C)OC(=O)C

Technology Process of alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate

There total 8 articles about alpha-D-Galactopyranose, 2-deoxy-2-[[(2,2,2-trichloroethoxy)carbonyl]amino]-, 1,3,4,6-tetraacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

acetic anhydride (108-24-7) + 2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose (172490-46-9) → 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose (122210-01-9,122210-05-3,145416-95-1,146864-65-5,114360-77-9)

Guidance literature:

In pyridine; at 20 ℃; for 12h;

DOI:10.1021/ja302099u

Reference yield: 92.0%

(+)-D-glucosamine hydrochloride (1078691-95-8) + acetic anhydride (108-24-7) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose (122210-01-9,122210-05-3,145416-95-1,146864-65-5,114360-77-9)

Guidance literature:

(+)-D-glucosamine hydrochloride; 2,2,2-Trichloroethyl chloroformate; With sodium hydrogencarbonate; In water; at 20 ℃; for 1h;

acetic anhydride; With pyridine; at 20 ℃;

DOI:10.1093/glycob/cwx017

Reference yield: 87.0%

1,3,4,6-tetra-O-acetyl-2-deoxy-2-{[(4-methoxyphenyl)methylidene]amino}-D-glucopyranose (114297-26-6) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose (122210-01-9,122210-05-3,145416-95-1,146864-65-5,114360-77-9)

Guidance literature:

1,3,4,6-tetra-O-acetyl-2-deoxy-2-{[(4-methoxyphenyl)methylidene]amino}-D-glucopyranose; With hydrogenchloride; water; In acetone; Reflux;

2,2,2-Trichloroethyl chloroformate; With pyridine; at 0 ℃; for 3h;

upstream raw materials:

acetic anhydride

2-deoxy-2-(2,2,2-trichloroethoxycarbonylamino)-D-glucopyranose

(3R,4R,5S,6R)-6-(acetoxymethyl)-3-aminotetrahydro-2H-pyran-2,4,5-triyl triacetate

2,2,2-Trichloroethyl chloroformate

Downstream raw materials:

(2R,3S,4R,5R,6S)-2-(acetoxymethyl)-6-(phenylthio)-5-(((2,2,2-trichloroethoxy)carbonyl)amino)tetrahydro-2H-pyran-3,4-diyl diacetate

phenyl 2-deoxy-3,4-O-(2,3-dimethoxybutane-2,3-diyl)-1-thio-6-O-p-toluenesulfonyl-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside

C₃₈H₅₄Cl₆N₂O₁₉S

phenyl 3,4,6-tri-O-acetyl-2-deoxy-1-thio-2-(2,2,2-trichloroethoxycarbonylamino)-β-D-glucopyranoside S-oxide