((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

Base Information

Chemical Name:((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol
CAS No.:124871-68-7
Molecular Formula:C₃₂H₄₈O₇Si
Molecular Weight:572.814
Hs Code.:

((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

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Chemical Property of ((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

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Technology Process of ((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

There total 11 articles about ((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124895-76-7
(2E,4S,5R,6R,7R)-4,6-dimethyl-7-(4-methoxybenzyloxy)-5,6-<1-(4-methoxyphenyl)ethylidenedioxy>-2-trimethylsilylmethylnon-2-en-1-ol

: 124871-68-7
((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -20 ℃; for 2.5h;
DOI:10.1248/cpb.37.1160

Reference yield:

: 17728-88-0
ethyl 3-(trimethylsilyl)propionate

: 124871-68-7
((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / LDA / tetrahydrofuran / -83 deg C, -20 deg C, 2 h

2: 90 percent / Et₃N / benzene / 0.33 h / 7 °C

3: 99 percent / NaOEt / tetrahydrofuran / 3.5 h / Ambient temperature

4: 78 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

5: m-CPBA / CH₂Cl₂ / 2.5 h / -20 °C

With lithium aluminium tetrahydride; sodium ethanolate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; benzene;
DOI:10.1248/cpb.37.1160

Reference yield:

: 27150-99-8
1,1-dimethoxy-1-(4-methoxyphenyl)ethane

: 124871-68-7
((2R,3R)-3-{(S)-1-[(4R,5R)-5-[(R)-1-(4-Methoxy-benzyloxy)-propyl]-2-(4-methoxy-phenyl)-2,5-dimethyl-[1,3]dioxolan-4-yl]-ethyl}-2-trimethylsilanylmethyl-oxiranyl)-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: CSA / CH₂Cl₂ / 2 h / Ambient temperature

2: 1N KOH / methanol / 18 h / Ambient temperature

3: 94 percent / oxalyl chloride / CH₂Cl₂; dimethylsulfoxide / 0.5 h / -60 - -50 °C

4: 99 percent / LDA / tetrahydrofuran / -83 deg C, -20 deg C, 2 h

5: 90 percent / Et₃N / benzene / 0.33 h / 7 °C

6: 99 percent / NaOEt / tetrahydrofuran / 3.5 h / Ambient temperature

7: 78 percent / LiAlH₄ / diethyl ether / 2 h / 0 °C

8: m-CPBA / CH₂Cl₂ / 2.5 h / -20 °C

With potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; camphor-10-sulfonic acid; sodium ethanolate; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.37.1160