Cyclopropanol, 2-phenyl-, (1R,2S)-

Base Information

• Chemical Name: Cyclopropanol, 2-phenyl-, (1R,2S)-
• CAS No.: 129518-69-0
• Molecular Formula: C9H10O
• Molecular Weight: 134.178
• Mol file: 129518-69-0.mol

Synonyms:

Chemical Property of Cyclopropanol, 2-phenyl-, (1R,2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanol, 2-phenyl-, (1R,2S)-

There total 14 articles about Cyclopropanol, 2-phenyl-, (1R,2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane (1240492-43-6) → (1R,2S)-(-)-2-phenyl-1-cyclopropane (129518-69-0)

Guidance literature:

With sodium perborate; water; In tetrahydrofuran; at 20 ℃; for 2.5h; optical yield given as %ee; Inert atmosphere;

DOI:10.1021/ja103783p

Reference yield: 48.0%

Dimethyl-(2-phenyl-cyclopropyl)-silanol → 2-Phenyl-cyclopropanol, opt.-inakt. (13830-40-5,13830-41-6,129518-69-0,90535-82-3)

Guidance literature:

With dihydrogen peroxide; potassium hydrogencarbonate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4039(96)02326-X

Reference yield:

(+/-)-4,4,5,5-tetramethyl-2-((1S,2R)-2-phenylcyclopropyl)-1,3,2-dioxaborolane (1240492-43-6) → (±)-4,4,5,5-tetramethyl-2-[2-phenylcyclopropyl]-1,3,2-dioxaborolane (1240492-43-6) + 2-Phenyl-cyclopropanol, opt.-inakt. (13830-40-5,13830-41-6,129518-69-0,90535-82-3)

Guidance literature:

With phosphite; Pseudomonas fluorescens 4-hydroxyacetophenone monooxygenase; phosphite dehydrogenase; oxygen; NADPH; In dimethyl sulfoxide; at 25 ℃; for 24h; pH=7.5; aq. buffer; Enzymatic reaction;

DOI:10.1016/j.tetasy.2012.05.004

upstream raw materials:

1-<β-Chlor-aethoxy>-2-phenyl-cyclopropan, opt.-inakt.

(E)-2-phenylethenyllithium

(E)-2-(phenyl)ethylenyldimethylsilanol

styrene

Downstream raw materials:

3,4,4-Triphenyl-butyraldehyde