1240492-43-6

Basic information

• Product Name: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid
• Synonyms: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid
• CAS NO: 1240492-43-6
• Molecular Formula: C7H11N3O2
• Molecular Weight: 169.18114
• EINECS: 945-690-2
• Mol File: 1240492-43-6.mol
• Article Data: 25

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid(1240492-43-6)
• EPA Substance Registry System: 5-tert-Butyl-4H-[1,2,4]triazole-3-carboxylic acid(1240492-43-6)

Safety Data

• Hazardous Substances Data: 1240492-43-6(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 1240492-12-9 (Z)-C₆H₅CHCHCH₂OP(O-iPr)2O 
• 73183-34-3 bis(pinacol)diborane 
• 1240492-11-8 (Z)-C₆H₅CHCHCH₂OP(O-2-ethylhexyl)2O 
• 1240492-42-5 bis(2-ethylhexyl) (2E)-3-phenylprop-2-en-1-yl phosphate 
• 84718-05-8 tert-butyl dimethyl((1-phenylprop-2-yn-1-yl)oxy)silane 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 160309-16-0 (R)-(-)-(1-phenyl-prop-2-ynyloxy)(tert-butyl)dimethylsilane 
• 4187-87-5 (R)-1-phenyl-2-propyn-1-ol 
• 83622-41-7 pinacol dichloromethylboronic ester 
• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 2066512-27-2 2-(diiodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 186581-53-3 diazomethane 

Relevant articles and documents

Borocyclopropanation of Styrenes Mediated by UV-light Under Continuous Flow Conditions

Herein, we report a user-friendly and metal-free UV-A light mediated borocyclopropanation of styrenes using continuous flow technology. A broad range of styrene derivatives can be cyclopropanated in good yields within 1 h residence time to produce highly

Design, synthesis, and biological evaluation of novel 2′-methyl-2′-fluoro-6-methyl-7-alkynyl-7-deazapurine nucleoside analogs as anti-Zika virus agents

Zika virus (ZIKV) is a mosquito-borne flavivirus and outbreaks of ZIKV have been reported in Africa, Americas and other parts of the world lately. The ZIKV epidemic has received extensive attention due to its ability to cause serious medical consequences and complications such as microcephaly and Guillain-Barre syndrome in recent years. Up to now, there are no specific treatments or vaccines available for ZIKV infection, which highlights the urgent need for developing new therapies. In this work, we designed and synthesized a series of novel 6-methyl-7-acetylenenyl-7-deazapurine nucleoside analogs as potential inhibitors of ZIKV replication. The biological activities against ZIKV replication were evaluated and the structure-activity relationship (SAR) was also studied. Among the compounds evaluated, nucleoside analog 38 (EC50 = 2.8 ± 0.8 μM, EC90 = 6.8 ± 2.3 μM) showed the most potent anti-ZIKV activity with low cytotoxicity (CC50 = 54.1 ± 6.9 μM) in an A549 based cellular model. The inhibitory activity of 38 was about 5 times more potent than the positive control NITD008. Notably, 38 showed similar inhibition potency against different ZIKV strains (ZG-01 and MR766) in a variety of host cell types including SNB19, A549, Huh7, Vero. In addition, 38 (Kd = 1.87 μM) has a stronger affinity to ZIKV RNA-dependent RNA polymerase (RdRp) protein than NITD008 (Kd = 3.43 μM) in the non-phosphorylation assay. These results indicated that compound 38 may serve as a promising candidate in future anti-ZIKV drug discovery.

Electrochemically promoted decarboxylative borylation of alkyl N-hydroxyphthalimide esters

An electrochemically promoted decarboxylative borylation reaction is reported. The reaction proceeds under mild conditions in an undivided cell without use of transition metal- or photo-catalysts. The key feature of the reaction is the compatibility of di

Reductive Ring-Opening 1,3-Difunctionalizations of Arylcyclopropanes with Sodium Metal

Sodium dispersion promotes reductive ring opening of arylcyclopropanes. The presence of a reduction-resistant electrophile, such as methoxypinacolatoborane, epoxide, oxetane, paraformaldehyde, or chlorotrimethylsilane, during the reductive ring opening event leads to the formation of 1,3-difunctionalized 1-arylalkanes by immediate trappings of the resulting two reactive carbanions. In particular, the ring-opening 1,3-diborylations of arylcyclopropanes afford 1,3-diborylalkanes with high syn selectivity.