Technology Process of 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid phenylamide; hydriodide
There total 10 articles about 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid phenylamide; hydriodide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 78 percent / H2 / Raney-Ni / methanol / 760 Torr
2: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h
3: PBr3 / CHCl3 / 1.5 h / Heating
4: C2H2ONa / ethanol / 5 h / Heating
5: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et2O, room temp. 2 h
6: SOCl2 / 1 h / Heating
7: 59 percent / benzene / 1.5 h / Ambient temperature
8: 72 percent / TEA, H2S / pyridine / Ambient temperature
9: 83.5 percent / acetone / Ambient temperature
10: 65 percent / 1.1M AcONH4 / ethanol / 2.5 h / Heating
With
hydrogenchloride; potassium hydroxide; thionyl chloride; C2H2ONa; TEA; hydrogen sulfide; ammonium acetate; hydrogen; phosphorus tribromide; sodium nitrite;
nickel;
In
pyridine; methanol; ethanol; chloroform; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 70 percent / NaBH4 / methanol
2: 78 percent / H2 / Raney-Ni / methanol / 760 Torr
3: 1.) HCl/NaNO2 / 1.) H2O; 2.) 0-5 deg C 30 min, room temp. 4 h
4: PBr3 / CHCl3 / 1.5 h / Heating
5: C2H2ONa / ethanol / 5 h / Heating
6: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et2O, room temp. 2 h
7: SOCl2 / 1 h / Heating
8: 59 percent / benzene / 1.5 h / Ambient temperature
9: 72 percent / TEA, H2S / pyridine / Ambient temperature
10: 83.5 percent / acetone / Ambient temperature
11: 65 percent / 1.1M AcONH4 / ethanol / 2.5 h / Heating
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; thionyl chloride; C2H2ONa; TEA; hydrogen sulfide; ammonium acetate; hydrogen; phosphorus tribromide; sodium nitrite;
nickel;
In
pyridine; methanol; ethanol; chloroform; acetone; benzene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: C2H2ONa / ethanol / 5 h / Heating
2: 1.) 6M HCl; 2.) 1M KOH / 1.) AcOH, reflux 3 h; 2.) Et2O, room temp. 2 h
3: SOCl2 / 1 h / Heating
4: 59 percent / benzene / 1.5 h / Ambient temperature
5: 72 percent / TEA, H2S / pyridine / Ambient temperature
6: 83.5 percent / acetone / Ambient temperature
7: 65 percent / 1.1M AcONH4 / ethanol / 2.5 h / Heating
With
hydrogenchloride; potassium hydroxide; thionyl chloride; C2H2ONa; TEA; hydrogen sulfide; ammonium acetate;
In
pyridine; ethanol; acetone; benzene;
