83101-14-8

Upstream product

• 6309-79-1 4-(3-Bromo-propyl)-benzoic acid 
• 623-26-7 terephthalonitrile 
• 109-64-8 1,3-dibromo-propane 
• 83101-11-5 γ-(4-Aminophenyl)propanol-hydrochlorid 
• 1734-79-8 3-(4-nitrophenyl)-2-propenal 
• 35271-56-8 3-(4-nitrophenyl)propyl-2-en-1-ol 
• 83101-12-6 4-(3-Hydroxypropyl)benzonitrile 

Downstream Products

• 872006-88-7 4-[3-(2-hydroxyethylamino)propyl]benzonitrile 
• 1093173-38-6 [5-(2-{4-[3-(4-cyanophenyl)propoxy]-3-trifluoromethylphenyl}ethyl)-2,2-dimethyl-1,3-dioxan-5-yl]carbamic acid t-butyl ester 
• 83101-88-6 5-(4-Carbamimidoyl-phenyl)-2-(naphthalene-1-sulfonylamino)-pentanoic acid phenylamide; hydriodide 
• 83101-83-1 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid phenylamide; hydriodide 
• 83101-81-9 4-[5-Oxo-5-piperidin-1-yl-4-(toluene-4-sulfonylamino)-pentyl]-benzamidine; hydriodide 
• 83101-82-0 5-(4-Carbamimidoyl-phenyl)-2-(toluene-4-sulfonylamino)-pentanoic acid butylamide; hydriodide 
• 83101-77-3 4-[4-(Naphthalene-2-sulfonylamino)-5-oxo-5-piperidin-1-yl-pentyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-78-4 4-[4-Butylcarbamoyl-4-(naphthalene-2-sulfonylamino)-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-73-9 4-[4-(Naphthalene-1-sulfonylamino)-5-oxo-5-piperidin-1-yl-pentyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-79-5 4-[4-(Naphthalene-2-sulfonylamino)-4-phenylcarbamoyl-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-75-1 4-[4-(Naphthalene-1-sulfonylamino)-4-phenylcarbamoyl-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-74-0 4-[4-Butylcarbamoyl-4-(naphthalene-1-sulfonylamino)-butyl]-thiobenzimidic acid methyl ester; hydriodide 
• 83101-89-7 4-[4-(Naphthalene-2-sulfonylamino)-5-oxo-5-piperidin-1-yl-pentyl]-benzamidine; hydriodide 
• 83101-90-0 5-(4-Carbamimidoyl-phenyl)-2-(naphthalene-2-sulfonylamino)-pentanoic acid butylamide; hydriodide 

Relevant academic research and scientific papers

AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF

Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.

Reductive activation of arenes 22. Reactions of the terephthalonitrile radical anion and dianion with α,ω-dibromoalkanes. New evidence for the charge transfer complex as a key intermediate in the reactions of the dianion

The major products of reactions of the terephthalonitrile radical anion with α,ω-dibromoalkanes Br(CH2)nBr (n = 3-5) were 4-(ω-bromoalkyl)benzonitriles. Analogous reactions of the terephthalonitrile dianion mainly yielded α,ω-bis(4-cyanophenyl) alkanes. Both transformations are convenient one-step routes to otherwise not easily accessible compounds that are valuable as versatile building blocks. The results of alkylation allow one to suggest that reactions of the dianion with intermediate 4-(ω-bromoalkyl)benzonitriles proceed more rapidly than those with the starting α,ω-dibromoalkanes. This was confirmed by competitive reactions of the dianion with 4-(ω-bromoalkyl)benzonitriles and the corresponding alkyl bromides. To explain such a ratio of the reaction rates, a mechanism was proposed for the reaction of the dianion with 4-(ω-bromoalkyl)benzonitriles. According to this mechanism, a charge transfer complex is a key reaction intermediate.

NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS

There is provided compounds of formula I, wherein R1, R2, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.