Technology Process of 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-methyl-amide trifluoroacetate salt
There total 9 articles about 6,7-dimethoxy-1-(3-methoxy-benzoyl)-isoquinoline-4-carboxylic acid methoxy-methyl-amide trifluoroacetate salt which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
water;
for 0.5h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: ethanol; sodium / toluene / 2 h / 80 - 85 °C
1.2: 2 h / 80 °C
2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
4.1: phosphorus pentachloride / dichloromethane / 20 °C
5.1: sulfur / 0.42 h / 165 °C
6.1: selenium(IV) oxide / acetic acid / 0.33 h / Heating / reflux
7.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux
8.1: triethylamine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C
8.2: 2 h / 20 °C
9.1: water / 0.5 h
With
hydrogenchloride; sodium hydroxide; selenium(IV) oxide; ethanol; phosphorus pentachloride; water; hydrogen; sodium; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
palladium 10% on activated carbon;
In
methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetic acid; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 2844.39 Torr
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane
3.1: phosphorus pentachloride / dichloromethane / 20 °C
4.1: sulfur / 0.42 h / 165 °C
5.1: selenium(IV) oxide / acetic acid / 0.33 h / Heating / reflux
6.1: sodium hydroxide; water / methanol / 1 h / Heating / reflux
7.1: triethylamine; isobutyl chloroformate / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 °C
7.2: 2 h / 20 °C
8.1: water / 0.5 h
With
hydrogenchloride; sodium hydroxide; selenium(IV) oxide; phosphorus pentachloride; water; hydrogen; benzotriazol-1-ol; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; isobutyl chloroformate;
palladium 10% on activated carbon;
In
methanol; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetic acid;
