2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Base Information

Chemical Name:2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester
CAS No.:501082-91-3
Molecular Formula:C₅₁H₆₇N₅O₁₀
Molecular Weight:910.12
Hs Code.:

2-[2-(2-{2-[2-<i>tert</i>-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6<i>H</i>-cyclopenta[<i>a</i>]phenanthren-17-yl ester

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Chemical Property of 2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

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Technology Process of 2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

There total 9 articles about 2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106624-70-8,41889-06-9
methyl (2S)-2-[[2-(t-butoxycarbonylamino)acetyl]amino]-3-phenylpropanoate

: 501082-91-3
2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 9 steps

1: HCl / ethyl acetate

2: DCC; HOBt

3: HCl / ethyl acetate

4: DCC; HOBt

5: 96 percent / 2 M aq. NaOH / 0 °C

6: 73 percent / DCC; HOBt

7: 88 percent / 2 M aq. NaOH / 0 °C

8: 67 percent / DCC; HOBt; NMM

9: H₂; HCOOH / 10 percent Pd/C / methanol

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; formic acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(02)00847-8

Reference yield:

: 63631-32-3
(S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate

: 501082-91-3
2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: HCl / ethyl acetate

2: DCC; HOBt

3: 96 percent / 2 M aq. NaOH / 0 °C

4: 73 percent / DCC; HOBt

5: 88 percent / 2 M aq. NaOH / 0 °C

6: 67 percent / DCC; HOBt; NMM

7: H₂; HCOOH / 10 percent Pd/C / methanol

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; formic acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(02)00847-8

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 501082-91-3
2-[2-(2-{2-[2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid 3-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: DCC; HOBt

2: HCl / ethyl acetate

3: DCC; HOBt

4: HCl / ethyl acetate

5: DCC; HOBt

6: 96 percent / 2 M aq. NaOH / 0 °C

7: 73 percent / DCC; HOBt

8: 88 percent / 2 M aq. NaOH / 0 °C

9: 67 percent / DCC; HOBt; NMM

10: H₂; HCOOH / 10 percent Pd/C / methanol

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; formic acid; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/S0960-894X(02)00847-8