3-(benzyloxy)cyclopentyl methanesulfonate

Base Information

• Chemical Name: 3-(benzyloxy)cyclopentyl methanesulfonate
• CAS No.: 905961-63-9
• Molecular Formula: C₁₃H₁₈O₄S
• Molecular Weight: 270.35
• Mol file: 905961-63-9.mol

Synonyms:

Chemical Property of 3-(benzyloxy)cyclopentyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)cyclopentyl methanesulfonate

There total 4 articles about 3-(benzyloxy)cyclopentyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + 1-benzyloxyl-3-hydroxylcyclopentane (905961-61-7) → 3-(benzyloxy)cyclopentyl methanesulfonate (905961-63-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 7h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00419

Reference yield:

1,3-dihydroxycyclopentane (16326-97-9,16326-98-0,59719-74-3) → 3-(benzyloxy)cyclopentyl methanesulfonate (905961-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 12 h / 25 °C

2.1: triethylamine / dichloromethane / 7 h / 0 - 25 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c00419

Reference yield:

benzyl bromide (100-39-0) → 3-(benzyloxy)cyclopentyl methanesulfonate (905961-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 12 h / 25 °C

2.1: triethylamine / dichloromethane / 7 h / 0 - 25 °C / Inert atmosphere

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c00419

upstream raw materials:

1,3-dihydroxycyclopentane

methanesulfonyl chloride

1-benzyloxyl-3-hydroxylcyclopentane

benzyl bromide