Technology Process of O-acetyl-β-(5-benzyloxy-2-iodo-4-methoxyphenyl)-N-(2-iodobenzyl)-N-methylethanolamine
There total 9 articles about O-acetyl-β-(5-benzyloxy-2-iodo-4-methoxyphenyl)-N-(2-iodobenzyl)-N-methylethanolamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 54.1 percent / K2CO3, mol. sieves 3A / ethanol / 3 h / Heating
2: 79.5 percent / I2, CF3COOAg / CHCl3 / 1 h
3: 72.5 percent / HCl / methanol / 7.5 h / Ambient temperature
4: 1) NaHCO3, 2) NaBH4 / 1) EtOH, 2 h, reflux, 2) EtOH, 2 h, reflux
5: 1) H3BO3, NaBH4, 2) pyridine / 1) MeOH, 1 h, 2) RT, 18 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; 3 A molecular sieve; iodine; boric acid; silver trifluoroacetate; sodium hydrogencarbonate; potassium carbonate;
In
methanol; ethanol; chloroform;
DOI:10.1248/cpb.37.1744
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 29.5 percent / LiAlH4 / tetrahydrofuran / 6 h / Ambient temperature
2: 54.1 percent / K2CO3, mol. sieves 3A / ethanol / 3 h / Heating
3: 79.5 percent / I2, CF3COOAg / CHCl3 / 1 h
4: 72.5 percent / HCl / methanol / 7.5 h / Ambient temperature
5: 1) NaHCO3, 2) NaBH4 / 1) EtOH, 2 h, reflux, 2) EtOH, 2 h, reflux
6: 1) H3BO3, NaBH4, 2) pyridine / 1) MeOH, 1 h, 2) RT, 18 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; 3 A molecular sieve; iodine; boric acid; silver trifluoroacetate; sodium hydrogencarbonate; potassium carbonate;
In
tetrahydrofuran; methanol; ethanol; chloroform;
DOI:10.1248/cpb.37.1744
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 79.5 percent / I2, CF3COOAg / CHCl3 / 1 h
2: 72.5 percent / HCl / methanol / 7.5 h / Ambient temperature
3: 1) NaHCO3, 2) NaBH4 / 1) EtOH, 2 h, reflux, 2) EtOH, 2 h, reflux
4: 1) H3BO3, NaBH4, 2) pyridine / 1) MeOH, 1 h, 2) RT, 18 h
With
pyridine; hydrogenchloride; sodium tetrahydroborate; iodine; boric acid; silver trifluoroacetate; sodium hydrogencarbonate;
In
methanol; chloroform;
DOI:10.1248/cpb.37.1744
