67387-79-5

Upstream product

• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 621-59-0 isovanillin 
• 100-39-0 benzyl bromide 
• 99307-41-2 2-(3-benzoxy-4-methoxyphenyl)-2-trimethylsiloxyacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 73898-59-6 1-(3-Benzyloxy-4-methoxy-phenyl)-2-nitro-ethanol 
• 67387-77-3 (3-Benzyloxy-4-methoxy-phenyl)-hydroxy-acetonitrile 

Downstream Products

• 78004-26-9 N-<2-Hydroxy-2-(3-benzyloxy-4-methoxyphenyl)ethyl>formamide 
• 6924-27-2 α-(aminomethyl)(3-hydroxy-4-methoxyphenyl)methanol 
• 67387-75-1 5-(3-benzyloxy-4-methoxy-phenyl)-oxazolidin-2-one 
• 125771-56-4 Acetic acid 2-[acetyl-(2-iodo-benzyl)-amino]-1-(5-benzyloxy-2-iodo-4-methoxy-phenyl)-ethyl ester 
• 125771-53-1 O-acetyl-β-(5-benzyloxy-2-iodo-4-methoxyphenyl)-N-(2-iodobenzyl)-N-methylethanolamine 
• 125771-54-2 Acetic acid 2-(benzyl-methyl-amino)-1-(5-benzyloxy-2-iodo-4-methoxy-phenyl)-ethyl ester 
• 125771-65-5 8-acetoxy-10-benzyloxy-11-methoxy-6-methyl-5,6,7,8-tetrahydrodibenzazocine 
• 125771-62-2 5-(5-Benzyloxy-2-iodo-4-methoxy-phenyl)-3-(2-iodo-benzyl)-oxazolidine 
• 125771-55-3 Acetic acid 2-(benzyl-methyl-amino)-1-(3-benzyloxy-4-methoxy-phenyl)-ethyl ester 
• 125771-52-0 β-(5-benzyloxy-2-iodo-4-methoxyphenyl)-N-(2-iodobenzyl)-N-methylethanolamine 
• 125771-51-9 β-(5-benzyloxy-2-iodo-4-methoxyphenyl)-N-(2-iodobenzyl)ethanolamine 
• 125771-68-8 10-benzyloxy-8-hydroxy-11-methoxy-6-methyl-5,6,7,8-tetrahydrodibenzazocine 
• 125771-59-7 N-[2-(5-Benzyloxy-2-iodo-4-methoxy-phenyl)-2-hydroxy-ethyl]-formamide 
• 125771-41-7 β-(5-benzyloxy-2-iodo-4-methoxyphenyl)ethanolamine 

Relevant academic research and scientific papers

ANTI-INFLAMMATORY COMPOUND, AND PREPARATION AND USE THEREOF

The present invention provides an anti-inflammatory compound, which is a compound having a structure (I) as shown below: The compound is a target that is important for autoimmune activation, and that has strong inhibitory effect on PDE4 and penetrates the skin easily, and is a new type anti-inflammatory compound that is easily degraded.

Use of 2-phenylmorpholin-5-one derivatives

A 2-phenylmorpholin-5-one derivative having the formula (I): wherein R1 represents a C1 to C8 alkyl group, a C3 to C7 cycloalkyl group or an indanyl group, R2 represents a C1 to C4 alkyl group, R3 represents a hydrogen atom, a C1 to C5 alkyl group, etc., R4 represents a hydrogen atom, a C1 to C6 alkyl group, etc., R5, R6 represent a hydrogen atom, a C1 to C5 alkyl group, etc.,an optical isomer thereof or a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof and a pharmaceutical composition containing the same.The above compound has a strong type IV phosphodiesterase (PDE) inhibitory activity and has bronchodilater and antiinflammatory effects.

5-(Substituted phenyl)-oxazolidinones and their sulfur analogs

Novel 5-(substituted phenyl)-oxazolidinones and their sulfur analogs of Formula I STR1 wherein R1 is optionally substituted lower alkyl, cycloalkyl or cycloalkylalkyl; R2 is hydrogen, optionally substituted lower alkyl, cycloalkyl, c

Synthesis and Structure-Activity Relationships among α-Adrenergic Receptor Agonists of the Phenylethanolamine Type

Nineteen arylethanolamine derivatives related to norepinephrine were prepared and tested for α-adrenergic stimulant activity.In one series the analogues possess a p-hydroxy function, while the meta position is substituted by methyl, ethyl, isopropyl, cyclohexyl, fluoro, chloro, iodo, carboxy, carbomethoxy, and methylsulfamido groups.The other series is meta hydroxylated with the para position substituted by the same groups.The influence of these groups upon the α-adrenergic activity is discussed, and the compounds are compared to octopamine, normetanephrine,norepinephrine, and norphenylephrine.It has been found that the introduction of an isopropyl, cyclohexyl, and fluoro group in the meta position of octopamine improves its affinity by three, five, and six times, respectively, whereas when these groups are introduced in the para position of norphenylephrine their effects are always detrimental.The most active compound, α-(aminomethyl)-(4-fluoro-3-hydroxyphenyl)methanol (44), has about one-hundreth the affinity and the same intrinsic activity as norepinephrine.