3-(4-Methylbenzylidene)dihydro-2(3H)-furanone

Base Information

Chemical Name:3-(4-Methylbenzylidene)dihydro-2(3H)-furanone
CAS No.:5418-24-6
Molecular Formula:C12H12 O2
Molecular Weight:188.2225
Hs Code.:
NSC Number:10427
ChEMBL ID:CHEMBL3193071

Synonyms:3-(4-Methylbenzylidene)dihydro-2(3H)-furanone;5418-24-6;NSC10427;NSC 10427;MLS000737926;(3E)-3-[(4-methylphenyl)methylidene]oxolan-2-one;CHEMBL3193071;HMS2886P13;NSC-10427;NCGC00246712-01;SMR000528090;(3E)-3-(p-tolylmethylene)tetrahydrofuran-2-one

Suppliers and Price of 3-(4-Methylbenzylidene)dihydro-2(3H)-furanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of 3-(4-Methylbenzylidene)dihydro-2(3H)-furanone

Chemical Property:

Vapor Pressure:8.18E-06mmHg at 25°C
Boiling Point:374.7°C at 760 mmHg
Flash Point:157.2°C
Density:1.174g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:188.083729621
Heavy Atom Count:14
Complexity:247

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C=C2CCOC2=O
Isomeric SMILES:CC1=CC=C(C=C1)/C=C/2\CCOC2=O

Technology Process of 3-(4-Methylbenzylidene)dihydro-2(3H)-furanone

There total 1 articles about 3-(4-Methylbenzylidene)dihydro-2(3H)-furanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

: 96-48-0
4-butanolide

: 104-87-0
4-methyl-benzaldehyde

: 5418-24-6
3-((Ξ)-4-methyl-benzylidene)-dihydro-furan-2-one

Guidance literature:: With sodium methylate; In methanol; at 0 ℃;
DOI:10.1016/j.tetlet.2016.06.005

Reference yield: 97.3%

: 32338-02-6
2-bromo-4-methoxyaniline

: 5418-24-6
3-((Ξ)-4-methyl-benzylidene)-dihydro-furan-2-one

: C₁₉H₂₀BrNO₃

Guidance literature:: With trimethylaluminum; In toluene;
DOI:10.1016/j.tetlet.2016.06.005

Reference yield:

: 5418-24-6
3-((Ξ)-4-methyl-benzylidene)-dihydro-furan-2-one

: C₁₉H₂₁NO₂

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylaluminum / toluene

2: pyridine / dichloromethane

3: caesium carbonate / N,N-dimethyl-formamide

4: 2,2'-azobis(isobutyronitrile) / toluene / Heating

5: lithium aluminium tetrahydride / tetrahydrofuran / Reflux

6: boron tribromide / dichloromethane

With pyridine; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); trimethylaluminum; boron tribromide; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2016.06.005