tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

Base Information

Chemical Name:tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate
CAS No.:1186125-45-0
Molecular Formula:C₄₅H₅₂ClN₅O₁₄S₂
Molecular Weight:986.518
Hs Code.:

tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

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Chemical Property of tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

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Technology Process of tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

There total 9 articles about tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₄₂ClN₃O₉S

: 245365-64-4
N-benzyloxycarbonyl-2-nitrobenzenesulfonamide

: 1186125-45-0
tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 4h; Inert atmosphere;
DOI:10.1039/b907983a

Reference yield:

: 1186125-42-7
(3R,4S)-8-[N-(2-chlorobenzyloxycarbonyl)amino]-3,4-[N-(2-nitrophenylsulfonyl)epimino]oct-1-ene

: 1186125-45-0
tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ozone / ethyl acetate / -78 °C

1.2: 0.08 h / -78 °C

2.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 1 h / 0 °C / Inert atmosphere

2.2: 3 h / 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 0 °C / Inert atmosphere

3.3: 1.5 h / -78 °C

4.1: fluorosilicic acid / methanol; acetonitrile / 0.5 h / 0 °C

5.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With fluorosilicic acid; di-isopropyl azodicarboxylate; tert.-butyl lithium; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate; toluene; acetonitrile;
DOI:10.1039/b907983a

Reference yield:

: C₂₁H₂₂ClN₃O₇S

: 1186125-45-0
tert-butyl (2R,5S,3E)-2-{4-[N-(benzyloxycarbonyl)-N-(2-nitrophenylsulfonyl)amino]butyl}-9-[N-(2-chlorobenzyloxycarbonyl)amino]-5-[N-(2-nitrophenylsulfonyl)amino]non-3-enoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine; lithium chloride / acetonitrile / 1 h / 0 °C / Inert atmosphere

1.2: 3 h / 0 - 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 0 °C / Inert atmosphere

2.3: 1.5 h / -78 °C

3.1: fluorosilicic acid / methanol; acetonitrile / 0.5 h / 0 °C

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

With fluorosilicic acid; di-isopropyl azodicarboxylate; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; methanol; diethyl ether; toluene; acetonitrile;
DOI:10.1039/b907983a