Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate

Base Information

Chemical Name:Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate
CAS No.:130048-08-7
Molecular Formula:C18H13ClFNO2
Molecular Weight:329.758
Hs Code.:
DSSTox Substance ID:DTXSID20563940
Wikidata:Q82448475

Synonyms:130048-08-7;Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate;ethyl 2-chloro-4-(4-fluorophenyl)-3-quinolinecarboxylate;SCHEMBL10474547;DTXSID20563940;CTYKESKGGABODQ-UHFFFAOYSA-N

Suppliers and Price of Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:329.0618845
Heavy Atom Count:23
Complexity:414

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C2=CC=CC=C2N=C1Cl)C3=CC=C(C=C3)F

Technology Process of Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate

There total 3 articles about Ethyl 2-chloro-4-(4-fluorophenyl)quinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 130954-99-3
ethyl 4-(4-fluorophenyl)-1,2-dihydro-2-oxo-3-quinolinecarboxylate

: 130048-08-7
ethyl 2-chloro-4-(4-fluorophenyl)-3-quinolinecarboxylate

Guidance literature:: With trichlorophosphate; for 1h; Heating;
DOI:10.1021/jm00105a057

Reference yield:

: 3800-06-4
2-amino-4'-fluorobenzophenone

: 130048-08-7
ethyl 2-chloro-4-(4-fluorophenyl)-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60.4 percent / piperidine / 144 h / 170 °C

2: 80.7 percent / phosphorus oxochloride / 2 h / Heating

With piperidine; trichlorophosphate;
DOI:10.1016/S0968-0896(01)00198-5

Reference yield:

: 105-53-3
diethyl malonate

: 130048-08-7
ethyl 2-chloro-4-(4-fluorophenyl)-3-quinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 60.4 percent / piperidine / 144 h / 170 °C

2: 80.7 percent / phosphorus oxochloride / 2 h / Heating

With piperidine; trichlorophosphate;
DOI:10.1016/S0968-0896(01)00198-5