pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Base Information

Chemical Name:pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester
CAS No.:820216-57-7
Molecular Formula:C₃₄H₄₂N₄O₆S₃Si
Molecular Weight:727.014
Hs Code.:

pyridine-3-sulfonic acid 3-(2-{2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1<i>H</i>-indol-7-yl ester

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Chemical Property of pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

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Technology Process of pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

There total 11 articles about pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 244081-35-4
(R)-3-(2-aminopropyl)-7-benzyloxyindole

: 820216-57-7
pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / CHCl₃

2: 99 percent / HCO₂NH₄ / Pd/C / methanol

3: TEA / CH₂Cl₂

4: HCl / ethyl acetate

5: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 244081-38-7
(2R)-7-benzyloxy-3-[2-(tert-butoxycarbonylamino)propyl]-1H-indole

: 820216-57-7
pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / HCO₂NH₄ / Pd/C / methanol

2: TEA / CH₂Cl₂

3: HCl / ethyl acetate

4: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; ammonium formate; potassium iodide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035

Reference yield:

: 16133-25-8
Pyridine-3-sulfonyl chloride

: 820216-57-7
pyridine-3-sulfonic acid 3-(2-{2-(tert-butyl-dimethyl-silanyloxy)-2-[3-(thiophene-2-sulfonylamino)-phenyl]-ethylamino}-propyl)-1H-indol-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TEA / CH₂Cl₂

2: HCl / ethyl acetate

3: i-PrNEt₂; KI / acetonitrile

With hydrogenchloride; N,N-diethyl-N-isopropylamine; TEA; potassium iodide; In dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2004.10.035