N-(2-chloroacetamidophenyl)pyrrole

Base Information

• Chemical Name: N-(2-chloroacetamidophenyl)pyrrole
• CAS No.: 37046-24-5
• Molecular Formula: C₁₂H₁₁ClN₂O
• Molecular Weight: 234.685
• Mol file: 37046-24-5.mol

Synonyms:

Chemical Property of N-(2-chloroacetamidophenyl)pyrrole

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

N1-[2-(1H-PYRROL-1-YL)PHENYL]-2-CHLOROACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-chloroacetamidophenyl)pyrrole

There total 5 articles about N-(2-chloroacetamidophenyl)pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-(1H-pyrrol-1-yl)aniline (6025-60-1) + Chloroacetic anhydride (541-88-8) → N-(2-chloroacetamidophenyl)pyrrole (37046-24-5)

Guidance literature:

for 1.5h;

Reference yield:

2-(1H-pyrrol-1-yl)aniline (6025-60-1) + chloroacetyl chloride (79-04-9) → N-(2-chloroacetamidophenyl)pyrrole (37046-24-5)

Guidance literature:

With pyridine; In 1,4-dioxane; Heating;

DOI:10.1021/jm960501o

Reference yield:

1-(2-nitrophenyl)-1H-pyrrole (33265-60-0) → N-(2-chloroacetamidophenyl)pyrrole (37046-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: BiCl₃-NaBH₄ / ethanol

2: dioxane / Heating

With bismuth(III) chloride; sodium tetrahydroborate; In 1,4-dioxane; ethanol;

DOI:10.1128/AAC.01306-05

upstream raw materials:

2-(1H-pyrrol-1-yl)aniline

Chloroacetic anhydride

chloroacetyl chloride

1-(2-nitrophenyl)-1H-pyrrole

Downstream raw materials:

2-Chloro-N-[2-(2-thiocyanato-pyrrol-1-yl)-phenyl]-acetamide

Refernces

• 1、 -. "SUBSTITUTED HETEROCYCLIC COMPOUNDS". Page 27. . Retrieved 2008/06/13.
• 2、 Cheeseman, G. W. H.,Hawi, A. A.,Varvounis, G.. "Synthesis of 5,6-Dihydropyrrolothiadiazocines". . p. 423 - 427. Retrieved 2007/10/02.