MBX-4132

Base Information

• Chemical Name: MBX-4132
• CAS No.: 2286411-30-9
• Molecular Formula: C₁₈H₁₅FN₄O₂
• Molecular Weight: 338.341
• Mol file: 2286411-30-9.mol

Synonyms:

Chemical Property of MBX-4132

Chemical Property:

• Density: 1.382±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

MBX-4132 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MBX-4132

There total 3 articles about MBX-4132 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1,2,3,4-tetrahydroisoquinoline (91-21-4) + 1,1'-carbonyldiimidazole (530-62-1) + 2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole (7659-07-6) → MBX-4132 (2286411-30-9)

Guidance literature:

1,1'-carbonyldiimidazole; 2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole; at 20 ℃; Molecular sieve;

1,2,3,4-tetrahydroisoquinoline; at 20 ℃;

DOI:10.1038/s41467-021-22012-7

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) + C12H8FN5O2 → MBX-4132 (2286411-30-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; for 0.0833333h;

Reference yield:

4-fluorobenzoyl hydrazide (456-06-4) → MBX-4132 (2286411-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; 1,4-dioxane / 0.17 h / 25 °C

1.2: 18.25 h / 25 °C

2.1: 1-methyl-pyrrolidin-2-one / 18 h / 65 °C

3.1: 1-methyl-pyrrolidin-2-one / 0.08 h

With sodium hydrogencarbonate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water;

upstream raw materials:

4-fluorobenzoyl hydrazide

1,2,3,4-tetrahydroisoquinoline

1,1'-carbonyldiimidazole

2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole