1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole

Base Information

• Chemical Name: 1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole
• CAS No.: 13034-76-9
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Hs Code.: 2933990090
• Mol file: 13034-76-9.mol

Synonyms:1,2,3,3-Tetramethylindoline;1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole;1H-Indole,2,3-dihydro-1,2,3,3-tetramethyl;

Chemical Property of 1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole

Chemical Property:

• Melting Point: 162 °C
• Boiling Point: 134-135 °C(Press: 15 Torr)
• PKA: 6.35±0.60(Predicted)
• PSA: 3.24000
• Density: 0.932±0.06 g/cm3(Predicted)
• LogP: 2.86750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole

There total 2 articles about 1,2,3,3-Tetramethyl-2,3-dihydro-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-Bis(1,3,3-trimethyl-2-indolinyl)-2-phospha-trimethinium-tetrafluoroborat → 1,3,3-Trimethyl-2-methyleneindoline (118-12-7) + 1,2,3,3-tetramethylindoline (13034-76-9) + 1,2,3,3-tetramethyl-3H-indolium tetrafluoroborate (21654-46-6)

Guidance literature:

With water; Product distribution; hydrolysis/protonation, also in chloroform (some weeks);

Reference yield:

1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) → 2,3,3-trimethylindoleniune (1640-39-7) + 1,2,3-trimethylindole (1971-46-6) + 1,2,3,3-tetramethylindoline (13034-76-9) + methyl iodide (74-88-4)

Guidance literature:

bei der Destillation im Vakuum;

Reference yield: 76.0%

1,2,3,3-tetramethylindoline (13034-76-9) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-[2-(4-hydroxyphenyl)ethenyl]-1,3,3-trimethyl-3H-indolium iodide (1193463-03-4,27945-11-5)

Guidance literature:

In ethanol; for 12h; Reflux;

DOI:10.1016/j.saa.2019.117625

upstream raw materials:

1,2,3,3-tetramethyl-3H-indolium iodide

Downstream raw materials:

2,3,3-trimethyl-2,3-dihydro-1H-indole

1,2,3,3-tetramethyl-5-(N-benzoyl-1,2-dihydroisoquinol-1-yl)-indoline

1,3,3-trimethyl-2-methylene-6-nitroindoline

1,2,3,3-tetramethyl-6-nitroindoline