1,2,3-Trimethyl-1H-indole

Base Information

• Chemical Name: 1,2,3-Trimethyl-1H-indole
• CAS No.: 1971-46-6
• Molecular Formula: C11H13N
• Molecular Weight: 159.231
• Hs Code.: 2933990090
• Mol file: 1971-46-6.mol

Synonyms:Indole,1,2,3-trimethyl;Indole,trimethyl-(7CI);1,2,3-Trimethyl-indol;1H-Indole, 1,2,3-trimethyl-;1,2,3-trimethyl-indole;trimethylindole;TRIMETHYL-1H-INDOLE;1H-Indole,trimethyl;1H-INDOLE,1,2,3-TRIMETHYL;1,2,3-Trimethyl-1H-indole;

Chemical Property of 1,2,3-Trimethyl-1H-indole

Chemical Property:

• Vapor Pressure: 0.00506mmHg at 25°C
• Melting Point: 18°C
• Refractive Index: 1.6110 (estimate)
• Boiling Point: 284.6°Cat760mmHg
• Flash Point: 125.9°C
• PSA: 4.93000
• Density: 0.99g/cm³
• LogP: 2.79510

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,2,3-Trimethyl-1H-indole

There total 3 articles about 1,2,3-Trimethyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethylindole (91-55-4) → 2,3,3-trimethylindoleniune (1640-39-7) + 1,2,3-trimethylindole (1971-46-6)

Guidance literature:

With diethyl ether; ammonia; sodium amide; anschl. mit Methyljodid;

DOI:10.1246/bcsj.32.838

Reference yield:

1,2,3,3-tetramethyl-3H-indolium iodide (5418-63-3) → 2,3,3-trimethylindoleniune (1640-39-7) + 1,2,3-trimethylindole (1971-46-6) + 1,2,3,3-tetramethylindoline (13034-76-9) + methyl iodide (74-88-4)

Guidance literature:

bei der Destillation im Vakuum;

Reference yield:

1-methyl-1H-indole-2,3-dione (2058-74-4) + methylmagnesium bromide (75-16-1) → 1,3-dimethylindole (875-30-9) + 1,2,3-trimethylindole (1971-46-6)

Guidance literature:

1-methyl-1H-indole-2,3-dione; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

In tetrahydrofuran; diethyl ether; for 2h; Overall yield = 68 %; Inert atmosphere; Reflux;

DOI:10.1039/c4cc04555f

upstream raw materials:

2,3-dimethylindole

1,2,3,3-tetramethyl-3H-indolium iodide

1-methyl-1H-indole-2,3-dione

methylmagnesium bromide

Downstream raw materials:

1,3-dimethyl-2-formylindole

Refernces