methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

Base Information

Chemical Name:methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate
CAS No.:1609575-83-8
Molecular Formula:C₁₄H₁₃NO₆
Molecular Weight:291.26
Hs Code.:

Synonyms:

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Chemical Property of methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

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Technology Process of methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

There total 3 articles about methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2965-22-2
methyl 2-fluoro-5-nitro-benzoate

: 1609575-83-8
methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

1.2: 15 h / Inert atmosphere; Reflux

2.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

3.1: sodium nitrite; nitric acid / water / 0.33 h / 0 °C

3.2: 62 - 70 °C

With 5%-palladium/activated carbon; hydrogen; nitric acid; sodium hydride; sodium nitrite; In tetrahydrofuran; methanol; water; mineral oil;
DOI:10.1021/jm500109z

Reference yield:

: 7304-32-7
2-fluoro-5-nitrobenzoic acid

: 1609575-83-8
methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 24 h / 0 °C / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

2.2: 15 h / Inert atmosphere; Reflux

3.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

4.1: sodium nitrite; nitric acid / water / 0.33 h / 0 °C

4.2: 62 - 70 °C

With thionyl chloride; 5%-palladium/activated carbon; hydrogen; nitric acid; sodium hydride; sodium nitrite; In tetrahydrofuran; methanol; water; mineral oil;
DOI:10.1021/jm500109z

Reference yield:

: 1026038-35-6
methyl 2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)-5-nitrobenzoate

: 1609575-83-8
methyl 5-cyano-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 5%-palladium/activated carbon; hydrogen / methanol / 12 h / 20 °C

2.1: sodium nitrite; nitric acid / water / 0.33 h / 0 °C

2.2: 62 - 70 °C

With 5%-palladium/activated carbon; hydrogen; nitric acid; sodium nitrite; In methanol; water;
DOI:10.1021/jm500109z