7H-1,7-NAPHTHYRIDIN-8-ONE

Base Information

• Chemical Name: 7H-1,7-NAPHTHYRIDIN-8-ONE
• CAS No.: 67967-11-7
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.14600
• Hs Code.: 2933990090
• Mol file: 67967-11-7.mol

Synonyms:7H-1,7-naphthyridin-8-one;

Chemical Property of 7H-1,7-NAPHTHYRIDIN-8-ONE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 237-239℃
• Boiling Point: 425.594oC at 760 mmHg
• PKA: 11.14±0.20(Predicted)
• Flash Point: 211.192oC
• PSA: 46.01000
• Density: 1.267g/cm3
• LogP: 1.33540
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1,7-Naphthyridin-8(7H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7H-1,7-NAPHTHYRIDIN-8-ONE

There total 12 articles about 7H-1,7-NAPHTHYRIDIN-8-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-(2,2-Dimethoxy-ethyl)-pyridine-2-carboxylic acid amide (97308-57-1) → 1,7-naphthyridinyl-8(7H)-one (67967-11-7)

Guidance literature:

With toluene-4-sulfonic acid; In benzene; for 20h; Heating;

Reference yield: 69.0%

3-[(E)-2-ethoxyvinyl]pyridine-2-carbonitrile → 1,7-naphthyridinyl-8(7H)-one (67967-11-7)

Guidance literature:

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In ethanol; water; Reflux;

DOI:10.1021/acs.joc.1c00472

Reference yield: 67.0%

8-amino-1,7-naphthyridine (17965-82-1) → 8-hydroxy-1,7-naphthyridine (67967-11-7)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 35 ℃; for 18h;

upstream raw materials:

2-hydroxy-3-aminopyridine

glycerol

3-(2,2-Dimethoxy-ethyl)-pyridine-2-carboxylic acid amide

3-bromopyridine-2-carbonitrile

Downstream raw materials:

7-benzyl-1,7-naphthyridin-8(7H)-one

8-chloro-[1,7]naphthyridine

5-bromo-7,8-dihydro-1,7-naphthyridin-8-one

Refernces

• 1、 -. "1-SUBSTITUTED 1,2,3,4-TETRAHYDRO-1,7-NAPHTHYRIDIN-8-AMINE DERIVATIVES AND THEIR USE AS EP4 RECEPTOR ANTAGONISTS". Paragraph 0279. . Retrieved 2017/02/09.
• 2、 Sakamoto, Takao,Kondo, Yoshinori,Yamanaka, Hiroshi. "Condensed Heteroaromatic Ring Systems. III. Synthesis of Naphthyridine Derivatives by Cyclization of Ethynylpyridinecarboxamides". . p. 626 - 633. Retrieved 2007/10/02.