N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysinamid

Base Information

• Chemical Name: N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysinamid
• CAS No.: 50557-87-4
• Molecular Formula: C₁₆H₂₃N₃O₄
• Molecular Weight: 321.376
• Mol file: 50557-87-4.mol

Synonyms:

Chemical Property of N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysinamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysinamid

There total 5 articles about N^α-Acetyl-N^ε-benzyloxycarbonyl-L-lysinamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride (27894-50-4) + acetic anhydride (108-24-7) → Nα-Acetyl-Nε-benzyloxycarbonyl-L-lysinamid (50557-87-4)

Guidance literature:

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride; acetic anhydride; With sodium hydroxide; In water; at -0.16 ℃; for 2h;

With ammonia; In methanol; at 20 ℃; Further stages.;

DOI:10.1016/j.jct.2006.03.015

Reference yield:

Nε-(benzyloxycarbonyl)-Nα-(tert-butoxycarbonyl)-L-lysinamide (55592-81-9) → Nα-Acetyl-Nε-benzyloxycarbonyl-L-lysinamid (50557-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / formic acid

2: Py, N-ethylmorpholine / dimethylformamide

With N-ethylmorpholine;; pyridine; hydrogenchloride; In formic acid; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19750580724

Reference yield:

N-α-tert-butyloxycarbonyl-N-ε-benzyloxycarbonyl-lysine p-nitrophenyl ester (2389-46-0) → Nα-Acetyl-Nε-benzyloxycarbonyl-L-lysinamid (50557-87-4)

Guidance literature:

Multi-step reaction with 3 steps

1: NH₃ / acetonitrile

2: aq. HCl / formic acid

3: Py, N-ethylmorpholine / dimethylformamide

With N-ethylmorpholine;; pyridine; hydrogenchloride; ammonia; In formic acid; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/hlca.19750580724

upstream raw materials:

N²-acetyl-N⁶-[(benzyloxy)carbonyl]-L-lysine

H-L-Lys(Z)-NH2

4-nitrophenol acetate

methyl (2S)-2-amino-6-{[(benzyloxy)carbonyl]amino}hexanoate hydrochloride