C₃₆H₅₀N₆O₁₁S

Base Information

• Chemical Name: C₃₆H₅₀N₆O₁₁S
• CAS No.: 274901-62-1
• Molecular Formula: C₃₆H₅₀N₆O₁₁S
• Molecular Weight: 774.893
• Mol file: 274901-62-1.mol

Synonyms:

Chemical Property of C₃₆H₅₀N₆O₁₁S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₅₀N₆O₁₁S

There total 12 articles about C₃₆H₅₀N₆O₁₁S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-Pent-4-enyl alcohol (821-09-0) → C36H50N6O11S (274901-62-1)

Guidance literature:

Multi-step reaction with 13 steps

1.1: 77 percent / NaH / tetrahydrofuran / Heating

2.1: 74 percent / mCPBA / CH₂Cl₂

3.1: 73 percent / methanol / 50 °C

4.1: hydrogen / 20percent Pd(OH)2 on carbon / dioxane; acetic acid; H₂O / 96 h / 2250.23 Torr

4.2: 93 percent / aq. NaOH / dioxane; H₂O / pH 8

5.1: 55 percent / triphenylphosphane; di-tert-butyl azodicarboxylate; HN₃ / tetrahydrofuran; benzene / 0 - 20 °C

6.1: 69 percent / triphenylphosphane; diisopropyl azodicarboxylate / tetrahydrofuran / -10 - 20 °C

7.1: sulfuryl chloride; acetic anhydride / CH₂Cl₂ / 1 h / -20 - -5 °C

8.1: 770 mg / triethylamine / CH₂Cl₂

9.1: 87 percent / NaIO₄ / RuCl₃*H₂O / CH₂Cl₂; acetonitrile; H₂O / 0.33 h / 0 - 20 °C

10.1: 100 percent / hydrogen / Pd/C / ethanol; CHCl₃ / 2.5 h / 2250.23 Torr

11.1: 65 percent / triethylamine / tetrahydrofuran

12.1: TFA / CH₂Cl₂ / 0.5 h

13.1: 133 mg / BOP; DIPEA / CH₂Cl₂

With sodium periodate; sulfuryl dichloride; tris-(2-chloro-ethyl)-amine; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; hydrogen; acetic anhydride; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; ruthenium trichloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; acetic acid; acetonitrile; benzene; 1.1: Condensation / 2.1: Epoxidation / 3.1: Addition / 4.1: Hydrogenolysis / 4.2: Condensation / 5.1: Substitution / 6.1: Mitsunobu reaction / 7.1: Substitution / 8.1: Substitution / 9.1: Oxidation / 10.1: Catalytic hydrogenation / 11.1: Substitution / 12.1: Hydrolysis / 13.1: Condensation;

DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

Reference yield:

1-(benzyloxy)-4,5-epoxypentane (112482-35-6) → C36H50N6O11S (274901-62-1)

Guidance literature:

Multi-step reaction with 11 steps

1.1: 73 percent / methanol / 50 °C

2.1: hydrogen / 20percent Pd(OH)2 on carbon / dioxane; acetic acid; H₂O / 96 h / 2250.23 Torr

2.2: 93 percent / aq. NaOH / dioxane; H₂O / pH 8

3.1: 55 percent / triphenylphosphane; di-tert-butyl azodicarboxylate; HN₃ / tetrahydrofuran; benzene / 0 - 20 °C

4.1: 69 percent / triphenylphosphane; diisopropyl azodicarboxylate / tetrahydrofuran / -10 - 20 °C

5.1: sulfuryl chloride; acetic anhydride / CH₂Cl₂ / 1 h / -20 - -5 °C

6.1: 770 mg / triethylamine / CH₂Cl₂

7.1: 87 percent / NaIO₄ / RuCl₃*H₂O / CH₂Cl₂; acetonitrile; H₂O / 0.33 h / 0 - 20 °C

8.1: 100 percent / hydrogen / Pd/C / ethanol; CHCl₃ / 2.5 h / 2250.23 Torr

9.1: 65 percent / triethylamine / tetrahydrofuran

10.1: TFA / CH₂Cl₂ / 0.5 h

11.1: 133 mg / BOP; DIPEA / CH₂Cl₂

With sodium periodate; sulfuryl dichloride; tris-(2-chloro-ethyl)-amine; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; hydrogen; acetic anhydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; ruthenium trichloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; acetic acid; acetonitrile; benzene; 1.1: Addition / 2.1: Hydrogenolysis / 2.2: Condensation / 3.1: Substitution / 4.1: Mitsunobu reaction / 5.1: Substitution / 6.1: Substitution / 7.1: Oxidation / 8.1: Catalytic hydrogenation / 9.1: Substitution / 10.1: Hydrolysis / 11.1: Condensation;

DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

Reference yield:

1-benzyloxy-4-pentene (81518-74-3) → C36H50N6O11S (274901-62-1)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 74 percent / mCPBA / CH₂Cl₂

2.1: 73 percent / methanol / 50 °C

3.1: hydrogen / 20percent Pd(OH)2 on carbon / dioxane; acetic acid; H₂O / 96 h / 2250.23 Torr

3.2: 93 percent / aq. NaOH / dioxane; H₂O / pH 8

4.1: 55 percent / triphenylphosphane; di-tert-butyl azodicarboxylate; HN₃ / tetrahydrofuran; benzene / 0 - 20 °C

5.1: 69 percent / triphenylphosphane; diisopropyl azodicarboxylate / tetrahydrofuran / -10 - 20 °C

6.1: sulfuryl chloride; acetic anhydride / CH₂Cl₂ / 1 h / -20 - -5 °C

7.1: 770 mg / triethylamine / CH₂Cl₂

8.1: 87 percent / NaIO₄ / RuCl₃*H₂O / CH₂Cl₂; acetonitrile; H₂O / 0.33 h / 0 - 20 °C

9.1: 100 percent / hydrogen / Pd/C / ethanol; CHCl₃ / 2.5 h / 2250.23 Torr

10.1: 65 percent / triethylamine / tetrahydrofuran

11.1: TFA / CH₂Cl₂ / 0.5 h

12.1: 133 mg / BOP; DIPEA / CH₂Cl₂

With sodium periodate; sulfuryl dichloride; tris-(2-chloro-ethyl)-amine; di-tert-butyl-diazodicarboxylate; di-isopropyl azodicarboxylate; hydrogen; acetic anhydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; trifluoroacetic acid; ruthenium trichloride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform; water; acetic acid; acetonitrile; benzene; 1.1: Epoxidation / 2.1: Addition / 3.1: Hydrogenolysis / 3.2: Condensation / 4.1: Substitution / 5.1: Mitsunobu reaction / 6.1: Substitution / 7.1: Substitution / 8.1: Oxidation / 9.1: Catalytic hydrogenation / 10.1: Substitution / 11.1: Hydrolysis / 12.1: Condensation;

DOI:10.1002/1099-0690(200004)2000:7<1219::AID-EJOC1219>3.0.CO;2-P

upstream raw materials:

n-Pent-4-enyl alcohol

1-(benzyloxy)-4,5-epoxypentane

1-benzyloxy-4-pentene

(2,5-dihydroxy-pentyl)-carbamic acid tert-butyl ester

Downstream raw materials:

C₄₅H₅₉N₇O₁₂S