4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE

Base Information

• Chemical Name: 4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE
• CAS No.: 13104-56-8
• Molecular Formula: C22H17N3O
• Molecular Weight: 339.396
• Hs Code.: 2933399090
• Mol file: 13104-56-8.mol

Synonyms:4′-(4-Methoxyphenyl)-2,2′﹕6′,2′′-terpyridine;QAEWAYWLMREGRA-UHFFFAOYSA;

Chemical Property of 4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE

Chemical Property:

• Melting Point: 167-168℃
• Boiling Point: 504.5oC at 760 mmHg
• PKA: 4.62±0.22(Predicted)
• Flash Point: 178.9oC
• PSA: 47.90000
• Density: 1.174g/cm3
• LogP: 4.88120
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

97% ^*data from raw suppliers

4'-(4-Methoxyphenyl)-2,2':6',2''-terpyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4'-(4-Methoxyphenyl)-2,2':6',2''-terpyridine is used as an organic chemical synthesis intermediate.

Technology Process of 4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE

There total 7 articles about 4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-acetylpyridine (1122-62-9) + 4-methoxy-benzaldehyde (123-11-5) → 2,6-bis(2'-pyridyl)-4-(p-methoxyphenyl)pyridine (13104-56-8)

Guidance literature:

With ammonium hydroxide; potassium hydroxide; In ethanol; at 20 ℃; for 8h;

DOI:10.1002/aoc.3714

Reference yield: 62.0%

1-(4-methoxyphenyl)-3-(2-pyridyl)propen-1-one (71858-72-5) + C10H10FNO3 → 2,6-bis(2'-pyridyl)-4-(p-methoxyphenyl)pyridine (13104-56-8)

Guidance literature:

1-(4-methoxyphenyl)-3-(2-pyridyl)propen-1-one; C₁₀H₁₀FNO₃; With caesium carbonate; In acetonitrile; at 40 ℃; for 1h;

With ammonium acetate; In acetonitrile; at 120 ℃; for 24h; regioselective reaction;

DOI:10.1021/acs.orglett.6b02883

Reference yield:

C22H20N2O3 → 2,6-bis(2'-pyridyl)-4-(p-methoxyphenyl)pyridine (13104-56-8)

Guidance literature:

With ammonium hydroxide; In various solvent(s); at 100 ℃; for 2h;

DOI:10.1055/s-2006-942525

upstream raw materials:

2-acetylpyridine

4-methoxy-benzaldehyde

1-(2-oxo-2-(2-pyridyl)ethyl)pyridinium iodide

(E)-2-(3-(p-methoxyphenyl)acryloyl)pyridine

Downstream raw materials:

4'-(4-hydroxyphenyl)-2,2';6',2''-terpyridine

4'-(4-Methoxy-phenyl)-[2,2';6',2'']terpyridine 1,1''-dioxide

{Pt(C₁₅H₁₀N₃(C₆H₄OCH₃))Cl}⁽¹⁺⁾*ClO₄^(1-)={Pt(C₁₅H₁₀N₃(C₆H₄OCH₃))Cl}ClO₄

[Ru^III(4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine)(Cl)₃]