Technology Process of (1R,2S,3R)-1-(2-(5-phenylisoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol
There total 3 articles about (1R,2S,3R)-1-(2-(5-phenylisoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-phenylisoxazole-3-carbonitrile;
With
sodium methylate;
In
methanol;
for 1h;
Inert atmosphere;
C6H13NO5;
With
acetic acid;
In
methanol;
for 18h;
Inert atmosphere;
With
sodium methylate;
In
methanol;
at 20 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/jm101183p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid / ethanol / 80 °C / Inert atmosphere
2.1: 10% palladium on activated charcoal; hydrogen; acetic acid / ethanol
3.1: sodium methylate / methanol / 1 h / Inert atmosphere
3.2: 18 h / Inert atmosphere
3.3: 24 h / 20 °C / Inert atmosphere
With
10% palladium on activated charcoal; hydrogen; sodium methylate; acetic acid;
In
methanol; ethanol;
1.1: Amadori rearrangement / 3.1: Bushi condenstation / 3.2: Bushi condensation / 3.3: Bushi condensation;
DOI:10.1021/jm101183p
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 10% palladium on activated charcoal; hydrogen; acetic acid / ethanol
2.1: sodium methylate / methanol / 1 h / Inert atmosphere
2.2: 18 h / Inert atmosphere
2.3: 24 h / 20 °C / Inert atmosphere
With
10% palladium on activated charcoal; hydrogen; sodium methylate; acetic acid;
In
methanol; ethanol;
2.1: Bushi condenstation / 2.2: Bushi condensation / 2.3: Bushi condensation;
DOI:10.1021/jm101183p
