(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Chemical Name:(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide
CAS No.:1350519-96-8
Molecular Formula:C₄₂H₅₃N₉O₇
Molecular Weight:795.939
Hs Code.:

(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Chemical Property of (4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

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Technology Process of (4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

There total 15 articles about (4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1350520-06-7
C₄₅H₆₅N₉O₁₀

: 1350519-96-8
(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2011.09.079

Reference yield:

: 1350519-99-1
C₂₆H₃₅N₃O₄

: 1350519-96-8
(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 24 h / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

4.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

4.2: 24 h / Inert atmosphere

5.1: triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.079

Reference yield:

: 1350520-01-2
C₃₄H₄₅N₅O₇

: 1350519-96-8
(4S,4aS,7S)-4-((S)-2-benzamido-5-guanidinopentanamido)-N-((S)-1-(1-(benzylamino)-1-oxo-3-phenylpropan-2-ylamino)-3-methyl-1-oxobutan-2-yl)-1-oxohexahydro-1H-pyrrolo[1,2-c][1,3]oxazine-7-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

2.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere

3.1: triethylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.09.079