(1SR,2SR)-1-methyl-2-phenylthiocyclohexanol

Base Information

• Chemical Name: (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol
• CAS No.: 125334-88-5
• Molecular Formula: C₁₃H₁₈OS
• Molecular Weight: 222.351
• Mol file: 125334-88-5.mol

Synonyms:

Chemical Property of (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol

There total 14 articles about (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

cis-1,2-epoxy-1-methylcyclohexane (1713-33-3) + thiophenol (108-98-5) → (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol (64833-04-1,101704-31-8,112261-09-3,125334-70-5,125334-88-5)

Guidance literature:

With borax; In water; at 20 ℃; for 7h;

DOI:10.1016/j.tetlet.2008.09.004

Reference yield: 90.0%

1,2-epoxy-1-methylcyclohexane (1713-33-3) + thiophenol (108-98-5) → anti-2-Methyl-2-phenylthiocyclohexanol (68771-21-1,104281-58-5,145285-86-5,145285-87-6) + (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol (64833-04-1,101704-31-8,112261-09-3,125334-70-5,125334-88-5)

Guidance literature:

With sodium hydroxide; In water; at 30 ℃; for 2h; pH=9.0;

DOI:10.1002/1615-4169(200206)344:3/4<379::AID-ADSC379>3.0.CO;2-4

Reference yield: 88.0%

1,2-epoxy-1-methylcyclohexane (1713-33-3) + diphenyldisulfane (882-33-7) → (1SR,2SR)-1-methyl-2-phenylthiocyclohexanol (64833-04-1,101704-31-8,112261-09-3,125334-70-5,125334-88-5)

Guidance literature:

diphenyldisulfane; benzyltriethylammonium tetrathiomolybdate; In acetonitrile; at 26 ℃; for 2h;

1,2-epoxy-1-methylcyclohexane; In ethanol; acetonitrile; at 26 ℃; for 7h; Further stages.;

DOI:10.1021/jo0263418

upstream raw materials:

2-phenylthiocyclohexanone

methyllithium

thiophenol

2-Chlorocyclohexanone

Downstream raw materials:

(1S,2S)-2-Benzenesulfinyl-1-methyl-cyclohexanol

1-methyl-6-phenylthiocyclohex-1-ene